Hyperglycemia and net transintestinal glucose and sodium transport in the rat.

Hyperglycemia produced by intravenous infusion of glucose cause, in the everted jejunum of rat, an increase of net transintestinal transport of glucose, Na and water without modifying their cell concentration. The concentration of glucose in the fluid pouring out at the serosal side is higher than the calculated intracellular concentration, especially in the experiments in which the serosal compartment is initially empty. This fact could be explained by the possible existence of an active extrusion mechanism in the basolateral membrane of the enterocyte.