Literature DB >> 7195549

Functional disconnection of brown adipose tissue in hypothalamic obesity in rats.

J Seydoux, F Rohner-Jeanrenaud, F Assimacopoulos-Jeannet, B Jeanrenaud, L Girardier.   

Abstract

The metabolic responses to electrical nerve stimulation, norepinephrine or octanoate additions were studied using continuous monitoring of NAD(P)H/NADP redox state by reflexion spectrophotometry of interscapular brown adipose tissues from control and ventromedial hypothalamic (VMH) lesioned rats. The responses to these stimuli were all greatly decreased already 3 days after VMH lesions, indicating a reduced cell capacity to oxidize free fatty acids. Measurements of interscapular brown adipose tissue composition 4-5 weeks after VMH lesions showed a decrease of both DNA concentration and total content, indicating some tissue involution. It is concluded that the involvement of the ventromedial hypothalamus in the activation of brown adipose tissue provided a possible anatomical clue concerning pathways connecting thermal and weight regulations.

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Year:  1981        PMID： 7195549     DOI： 10.1007/bf00582702

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  15 in total

1.  Determination of nucleic acids in animal tissues.

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3.  A microspectrophotometric method for the determination of cytochrome oxidase.

Authors:  S J COOPERSTEIN; A LAZAROW
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4.  Control of brown fat thermogenesis by the sympathetic nervous system.

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Journal:  Nature       Date:  1979-09-06       Impact factor: 49.962

6.  Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue.

Authors:  T Shimazu; A Takahashi
Journal:  Nature       Date:  1980-03-06       Impact factor: 49.962

7.  Ventromedial hypothalamic lesions and the mobilization of fatty acids.

Authors:  Y Nishizawa; G A Bray
Journal:  J Clin Invest       Date:  1978-03       Impact factor: 14.808

8.  In vitro study of the control of the metabolic activity of brown adipose tissue by the sympathetic nervous system.

Authors:  J Seydoux; J Constantinidis; M Tsacopoulos; L Girardier
Journal:  J Physiol (Paris)       Date:  1977

9.  Consequences of ventromedial hypothalamic lesions on metabolism of perfused rat liver.

Authors:  C Karakash; B E Hustvedt; A Lovo; Y Le Marchand; B Jeanrenaud
Journal:  Am J Physiol       Date:  1977-03

10.  Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesis.

Authors:  N J Rothwell; M J Stock
Journal:  Pflugers Arch       Date:  1981-03       Impact factor: 3.657
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  9 in total

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Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

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Journal:  Pflugers Arch       Date:  1993-07       Impact factor: 3.657

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Authors:  C M Blatteis; M Banet
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Authors:  N J Rothwell; M J Stock; A J Thexton
Journal:  J Physiol       Date:  1983-09       Impact factor: 5.182

7.  Acute effects of food, 2-deoxy-D-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats.

Authors:  N J Rothwell; M E Saville; M J Stock
Journal:  Pflugers Arch       Date:  1981-12       Impact factor: 3.657

8.  Specific thermal responsiveness of ventromedial hypothalamic neurons to localized scrotal heating and cooling in rats.

Authors:  Q Li; J Thornhill
Journal:  J Physiol       Date:  1996-05-01       Impact factor: 5.182

Review 9.  The contribution of Swiss scientists to the assessment of energy metabolism.

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  9 in total

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