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Literature DB >> 7195467

Isolation of a lethal toxin from Cortinarius orellanus Fr.

Abstract

The fungal toxin 'orellanine', isolated by Grzymala (10) from Cortinarius orellanus, seems to be a heterogeneous mixture of several toxic and nontoxic substances. We succeeded in isolating a lethal toxin which is sensitive to light and which is striking because of its long latency period. We consider this the main toxin of C. orellanus. Even in extremely high doses of ten times LD 100 mice do not die earlier than 48 hours after application. The paper gives details about the isolation and several properties of this slow acting toxin.

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Year: 1981 PMID： 7195467 DOI： 10.1007/bf01259460

Source DB: PubMed Journal: Mycopathologia ISSN： 0301-486X Impact factor: 2.574

7 in total

1. Separation of complex mixtures of polyhydroxy phenols on columns of Sephadex.

Authors: J B Woof; J S Pierce
Journal: J Chromatogr Date: 1967-05

2. Analysis of the toxins of amanitin-containing mushrooms.

Authors: H Faulstich; D Georgopoulos; M Bloching; T Wieland
Journal: Z Naturforsch C Biosci Date: 1974 Jan-Feb

Review 3. The toxic peptides of Amanita phalloides.

Authors: T Wieland
Journal: Fortschr Chem Org Naturst Date: 1967

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Authors: T Wieland
Journal: Naturwissenschaften Date: 1972-06

5. The separation of phenolic glucosides and carbohydrates from the bark of Populus tremula by gel filtration.

Authors: A Repas; B Nikolin
Journal: J Chromatogr Date: 1968-05-21

6. Damage caused by two finnish mushrooms, Cortinarius speciosissimus and Cortinarius gentilis on the rat kidney.

Authors: M Möttönen; L Nieminen; H Heikkilä
Journal: Z Naturforsch C Biosci Date: 1975 Sep-Oct

7. Individual variation in mushroom poisoning induced in the male rate by Cortinarius speciosissimus.

Authors: L Nieminen; K Pyy
Journal: Med Biol Date: 1976-04

7 in total

1. Toxic properties of the mushroom Cortinarius orellanus. I. Chemical characterization of the main toxin of Cortinarius orellanus (Fries) and Cortinarius speciosissimus (Kühn & Romagn) and acute toxicity in mice.

Authors: H Prast; E R Werner; W Pfaller; M Moser
Journal: Arch Toxicol Date: 1988-08 Impact factor: 5.153

Isolation of a lethal toxin from Cortinarius orellanus Fr.

1. Separation of complex mixtures of polyhydroxy phenols on columns of Sephadex.

2. Analysis of the toxins of amanitin-containing mushrooms.

Review 3. The toxic peptides of Amanita phalloides.

4. [Structure and mode of action of the amatoxins].

5. The separation of phenolic glucosides and carbohydrates from the bark of Populus tremula by gel filtration.

6. Damage caused by two finnish mushrooms, Cortinarius speciosissimus and Cortinarius gentilis on the rat kidney.

7. Individual variation in mushroom poisoning induced in the male rate by Cortinarius speciosissimus.

1. Toxic properties of the mushroom Cortinarius orellanus. I. Chemical characterization of the main toxin of Cortinarius orellanus (Fries) and Cortinarius speciosissimus (Kühn & Romagn) and acute toxicity in mice.

2. Cortinarius speciosissimus toxins--a preliminary report.

3. Intoxication by Cortinarius orellanus: detection and assay of orellanine in biological fluids and renal biopsies.

4. Mushroom toxins of the genus Cortinarius.

5. Investigations on the mode of action of the fungus toxin orellanine on renal cell cultures.

Review 6. Mushroom poisoning caused by species of the genus Cortinarius Fries.

7. Long-term clinical outcome for patients poisoned by the fungal nephrotoxin orellanine.