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Literature DB >> 7193541

Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine.

Abstract

Cell-mediated immunity is invariably impaired in protein-energy malnutrition. The effect of selected nutrient deficiencies on serum thymic factor activity was assessed in deprived rats and pair-fed controls. Deficits of calories, zinc or pyridoxine resulted in significant lowering of serum thymic factor activity whereas vitamin A deficiency did not have any effect. It is suggested that variants nutrients modulate different steps of cell-mediated immunity and that reduced thymic hormone activity may be the underlying mechanism of imparied immunity in some but not all nutritional deficiencies.

Entities: Chemical Disease Species

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Year: 1980 PMID： 7193541 PMCID： PMC1537084

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

14 in total

1. Abnormal cellular immune responses during acquired zinc deficiency.

Authors: R S Pekarek; H H Sandstead; R A Jacob; D F Barcome
Journal: Am J Clin Nutr Date: 1979-07 Impact factor: 7.045

2. Effects of vitamin B6 deficiency on thymic epithelial cells and T lymphocyte differentiation.

Authors: J I Willis-Carr; R L St Pierre
Journal: J Immunol Date: 1978-04 Impact factor: 5.422

3. Vitamin B6 deficiency and the lymphoid system. I. Effects on cellular immunity and in vitro incorporation of 3H-uridine by small lymphocytes.

Authors: L C Robson; M R Schwarz
Journal: Cell Immunol Date: 1975-03 Impact factor: 4.868

4. I. Depressed immunological function in zinc-deprived rats as measured by mitogen response of spleen, thymus, and peripheral blood.

Authors: R L Gross; N Osdin; L Fong; P M Newberne
Journal: Am J Clin Nutr Date: 1979-06 Impact factor: 7.045

5. Enzymatic and morphological response of the thymus to drugs in normal and zinc-deficient pregnant rats and their fetuses.

Authors: R Gossrau; H J Merker; T Günther; R Graf; J Vormann
Journal: Histochemistry Date: 1987

5 in total

Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine.

1. Abnormal cellular immune responses during acquired zinc deficiency.

2. Effects of vitamin B6 deficiency on thymic epithelial cells and T lymphocyte differentiation.

3. Vitamin B6 deficiency and the lymphoid system. I. Effects on cellular immunity and in vitro incorporation of 3H-uridine by small lymphocytes.

4. I. Depressed immunological function in zinc-deprived rats as measured by mitogen response of spleen, thymus, and peripheral blood.

5. Studies on thymus products. II. Demonstration and characterization of a circulating thymic hormone.

6. Effect of vitamin A and protein-calorie undernutrition on immune responses.

7. Circulating thymic hormone levels in zinc deficiency.

8. Regeneration of T-cell helper function in zinc-deficient adult mice.

9. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice.

10. The effect of vitamin A deficiency on the in vitro cellular immune response of rats.

1. Numerical and functional deficiency in T helper cells in protein energy malnutrition.

2. Contribution of zinc and other metals to the biological activity of the serum thymic factor.

3. Cell-mediated immune responses in zinc-deficient animals.

4. Growth hormone treatment stimulates thymulin production in aged dogs.

5. Enzymatic and morphological response of the thymus to drugs in normal and zinc-deficient pregnant rats and their fetuses.