Literature DB >> 7193534

A peculiar toxicity manifested by platinum(II)amines in rats: gastric distension after intraperitoneal administration.

I A Roos, D P Fairlie, M W Whitehouse.   

Abstract

Metoclopramide i.p. reduces the gastric distension consistently seen in rats given cisplatin i.p. at effective immunosuppressant doses (6 mg/kg). Many other immunosuppressant/oncolytic platinum amines also engendered gastric distension but certain dimers and 1,2-cyclohexanediaminoplatinum (II) compounds did not. This phenomenon appears to be due to paralysis of gastric emptying (without appetite suppression).

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Year:  1981        PMID： 7193534     DOI： 10.1016/0009-2797(81)90066-1

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  2 in total

1.  Antiemetic effect and pharmacokinetics of high dose metoclopramide in cancer patients treated with cisplatin-containing chemotherapy regimens.

Authors:  H Havsteen; H Nielsen; M Kjaer
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

2.  In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats.

Authors:  Osama A Badary; Azza S Awad; Mohey A Sherief; Farid M A Hamada
Journal:  World J Gastroenterol       Date:  2006-09-07       Impact factor: 5.742
  2 in total

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