Literature DB >> 7193464

Secretin and VIP-stimulated adenylate cyclase from rat heart. II. Impairment in spontaneous hypertension.

P Chatelain, P Robberecht, P De Neef, J C Camus, D Heuse, J Christophe.   

Abstract

Cardiac adenylate cyclase activity was normal in 3 weeks-old spontaneously hypertensive rats of the Wistar-Okamoto substrain. The hormone-sensitive adenylate cyclase activity was reduced in 10 weeks-old or older animals, and secretin- and VIP-activations were definitely more impaired (by 64% and 69%, respectively) than isoproterenol- and glucagon-activations (17% and 22%, respectively). By contrast, the fluoride- and p[NH]ppG-stimulations of the enzyme were unaffected. These alterations in the adenylate cyclase system coupled to secretin and VIP appeared specific to the heart as the isolated pancreatic acinar cells from spontaneously hypertensive animals responded normally to secretin, as a liver particulate fraction responded normally to secretin and VIP, and both brain synaptic membranes and a particulate fraction of anterior pituitary to VIP.

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Year:  1980        PMID： 7193464     DOI： 10.1007/bf00587925

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  34 in total

1.  Pituitary response to TRH and LHRH in spontaneously hypertensive rats.

Authors:  J R Sowers; G Tempel; G Resch; M Colantino
Journal:  Proc Soc Exp Biol Med       Date:  1978-12

Review 2.  Hormonal regulation of peptide receptors and target cell responses.

Authors:  K J Catt; J P Harwood; G Aguilera; M L Dufau
Journal:  Nature       Date:  1979-07-12       Impact factor: 49.962

3.  Adentylate cyclase activity in myocardium of spontaneously hypertensive rat: effect of endogenous factors and solubilization.

Authors:  R C Bhalla; R V Sharma; A T Ashley
Journal:  Biochem Biophys Res Commun       Date:  1978-05-15       Impact factor: 3.575

4.  Changes in cyclic nucleotide metabolism in aorta and heart of neurogenically hypertensive rats: possible trigger mechanism of hypertension.

Authors:  M S Amer; N Doba; D J Reis
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

5.  Cyclic AMP in pancreatic acinar cells: effects of gastrointestinal hormones.

Authors:  J D Gardner; T P Conlon; T D Adams
Journal:  Gastroenterology       Date:  1976-01       Impact factor: 22.682

Review 6.  Vasoactive intestinal polypeptide: measurement, distribution and putative neurotransmitter function.

Authors:  J Fahrenkrug
Journal:  Digestion       Date:  1979       Impact factor: 3.216

7.  Secretin and VIP-stimulated adenylate cyclase from rat heart. I. General properties and structural requirements for enzyme activation.

Authors:  P Chatelain; P Robberecht; P De Neef; M Deschodt-Lanckman; W König; J Christophe
Journal:  Pflugers Arch       Date:  1980-12       Impact factor: 3.657

8.  Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat.

Authors:  J M Saavedra; H Grobecker; J Axelrod
Journal:  Circ Res       Date:  1978-04       Impact factor: 17.367

9.  Development of left ventricular hypertrophy in young spontaneously hypertensive rats after peripheral sympathectomy.

Authors:  A F Cutilletta; L Erinoff; A Heller; J Low; S Oparil
Journal:  Circ Res       Date:  1977-04       Impact factor: 17.367

10.  Studies on dispersed pancreatic exocrine cells. I. Dissociation technique and morphologic characteristics of separated cells.

Authors:  A Amsterdam; J D Jamieson
Journal:  J Cell Biol       Date:  1974-12       Impact factor: 10.539
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  3 in total

1.  Regulation of cardiac adenylate cyclase activity in rodent models of obesity.

Authors:  D Strassheim; M D Houslay; G Milligan
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

2.  Topographical distribution of the secretin- and VIP-stimulated adenylate cyclase system in the heart of five animal species.

Authors:  P Chatelain; P Robberecht; M Waelbroeck; P De Neef; J C Camus; A N Huu; J Roba; J Christophe
Journal:  Pflugers Arch       Date:  1983-04       Impact factor: 3.657

3.  The cardiac inotropic response to secretin is lower in genetically obese (fa/fa) than in lean (fa/?) Zucker rats.

Authors:  P Robberecht; P De Neef; J C Camus; M Waelbroeck; J Fontaine; J Christophe
Journal:  Pflugers Arch       Date:  1983-08       Impact factor: 3.657
  3 in total

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