Determination of the optimal feeding regime during biosynthesis of erythromycin.

A systems approach to the analysis of the process of fermentaton of erythromycin in demonstrated. On the basis of biochemical and bioengineering data obtained in hydrodynamic tests and pilot plant fermentations of erythromycin a mathematical model for optimal technological parameters of growth of Streptomyces erythreus and product formation was postulated. The optimal regime was simulated and subsequently verified. The production of erythromycin increased to 112%.