Literature DB >> 7191065

Naloxone overcomes the dopaminergic, EEG, and behavioral effects of gamma-hydroxybutyrate.

O C Snead, L J Bearden.   

Abstract

The specific opiate antagonists--naloxone and naltrexone--attenuated or abolished the electrical seizure activity, behavioral abnormalities, and increased striatal dopamine content produced by gamma-butyrolactone, the prodrug of gamma-hydroxybutyrate. The effects of naloxone and naltrexone were dose-dependent. These data suggest that gamma-hydroxybutyric acid exerts its effects by action either at the opiate receptor or on enkephalinergic systems, which may be involved in petit mal epilepsy.

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Year:  1980        PMID： 7191065     DOI： 10.1212/wnl.30.8.832

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  7 in total

Review 1.  gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness.

Authors:  Daniel Pardi; Jed Black
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Comparison of N-methyl-2-pyrrolidone (NMP) and the "date rape" drug GHB: behavioral toxicology in the mouse model.

Authors:  Raffaella Arfè; Sabrine Bilel; Micaela Tirri; Paolo Frisoni; Giovanni Serpelloni; Margherita Neri; Federica Boccuto; Tatiana Bernardi; Federica Foti; Fabio De-Giorgio; Matteo Marti
Journal:  Psychopharmacology (Berl)       Date:  2021-04-21       Impact factor: 4.530

3.  Neuroleptic-like effects of gamma-hydroxybutyrate: interactions with haloperidol and dizocilpine.

Authors:  Rajkumar J Sevak; Charles P France; Wouter Koek
Journal:  Eur J Pharmacol       Date:  2004-01-12       Impact factor: 4.432

Review 4.  Behavioral analyses of GHB: receptor mechanisms.

Authors:  Lawrence P Carter; Wouter Koek; Charles P France
Journal:  Pharmacol Ther       Date:  2008-10-29       Impact factor: 12.310

5.  Effect of gammahydroxybutyric acid on catecholamine synthesis and utilization in the developing rat brain.

Authors:  T Hedner; P Lundborg
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

6.  Heightened eating drive and visual food stimuli attenuate central nociceptive processing.

Authors:  Hazel Wright; Xiaoyun Li; Nicholas B Fallon; Timo Giesbrecht; Anna Thomas; Joanne A Harrold; Jason C G Halford; Andrej Stancak
Journal:  J Neurophysiol       Date:  2014-12-04       Impact factor: 2.714

Review 7.  Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency.

Authors:  Patrizia Malaspina; Matthew J Picklo; C Jakobs; O Carter Snead; K Michael Gibson
Journal:  Hum Genomics       Date:  2009-01       Impact factor: 4.639
  7 in total

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