A crossover study comparing the kinetics of Tc-99m-labeled diethyl- and diisopropyl-IDA.

Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-diethyl-IDA (DE-IDA) were compared in each of 44 patients who had serum bilirubin levels ranging from normal to 50 mg/dl. Quantitative and qualitative analysis showed a significantly higher liver uptake relative to background for DISIDA. No significant differences between DISIDA and DE-IDA were found in the blood retention and rate of liver washout. Clinically, the diagnostic information received from both radiopharmaceuticals was essentially the same.