Literature DB >> 7190019

Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.

I J Stratford, C Williamson, G E Adams.   

Abstract

cis-Dichlorodiammineplatinum(II) (cis-Pt(II) can act as a radiosensitizer of hypoxic mammalian cells in vitro. Used in combination with misonidazole the level of sensitization achieved is greater than that seen with either drug alone, and it is suggested that these compounds sensitize by independent mechanisms. For cells held at 37 degrees C, cis-Pt(II) shows much greater toxicity to hypoxic cells than to aerobic cells. In combination with misonidazole, no additional cytotoxic effect is shown towards aerobic cells than that seen for cis-Pt(II) alone. However, there is additional killing of hypoxic cells when they are treated with both drugs.

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Year:  1980        PMID： 7190019      PMCID： PMC2010266          DOI： 10.1038/bjc.1980.93

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  16 in total

1.  Hypoxic sensitizers: radiobiological studies at the cellular level.

Authors:  E J Hall; L Roizin-Towle
Journal:  Radiology       Date:  1975-11       Impact factor: 11.105

2.  Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro.

Authors:  B C Cooke; E M Fielden; M Johnson
Journal:  Radiat Res       Date:  1976-01       Impact factor: 2.841

3.  Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

Authors:  R Sridhar; C Koch; R Suterland
Journal:  Int J Radiat Oncol Biol Phys       Date:  1976 Nov-Dec       Impact factor: 7.038

4.  Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.

Authors:  B A Moore; B Palcic; L D Skarsgard
Journal:  Radiat Res       Date:  1976-09       Impact factor: 2.841

5.  Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum (II).

Authors:  R C Richmond; J D Zimbrick; D L Hykes
Journal:  Radiat Res       Date:  1977-08       Impact factor: 2.841

6.  Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II).

Authors:  R C Richmond; E L Powers
Journal:  Radiat Res       Date:  1976-11       Impact factor: 2.841

7.  Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.

Authors:  G E Adams; I R Flockhart; C E Smithen; I J Stratford; P Wardman; M E Watts
Journal:  Radiat Res       Date:  1976-07       Impact factor: 2.841

8.  Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

Authors:  I J Stratford; G E Adams
Journal:  Br J Cancer       Date:  1977-03       Impact factor: 7.640

9.  The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro.

Authors:  I Szumiel; A H Nias
Journal:  Br J Cancer       Date:  1976-04       Impact factor: 7.640

10.  Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.

Authors:  S Dische; M I Saunders; M E Lee; G E Adams; I R Flockhart
Journal:  Br J Cancer       Date:  1977-05       Impact factor: 7.640
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  6 in total

1.  Radiosensitisers.

Authors: 
Journal:  Br Med J       Date:  1980-10-25

2.  Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.

Authors:  E O Pettersen; T Lindmo
Journal:  Br J Cancer       Date:  1981-03       Impact factor: 7.640

3.  Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions.

Authors:  I Tannock; P Guttman
Journal:  Br J Cancer       Date:  1981-02       Impact factor: 7.640

Review 4.  Convection-Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy.

Authors:  Minghan Shi; Léon Sanche
Journal:  J Oncol       Date:  2019-07-22       Impact factor: 4.375

5.  Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability.

Authors:  N M Hasan; G E Adams; M C Joiner; J F Marshall; I R Hart
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640

6.  The binding of cis-dichlorodiammineplatinum(II) to extracellular and intracellular compounds in relation to drug uptake and cytotoxicity in vitro.

Authors:  J E Melvik; J M Dornish; E O Pettersen
Journal:  Br J Cancer       Date:  1992-08       Impact factor: 7.640
  6 in total

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