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Literature DB >> 7188836

Exocytosis of residual bodies in a lysosomal storage disease.

Abstract

Scanning and transmission electron-microscopic study of the livers of 2 kittens suffering from GM2 gangliosidosis revealed discontinuities in the plasma membrane of hepatocytes and Kupffer cells, indicating an attempt by the cells to free themselves of excess lysosomal residues by means of exocytosis. Inclusions morphologically similar to those seen in the hepatocytes were observed in the perisinusoidal space. Openings were seen on all surfaces of the hepatocytes. Such extrusion of lysosomal residues is an example of a mechanism rarely observed in viable metazoan cells.

Entities: Disease

Mesh：

Year: 1980 PMID： 7188836 PMCID： PMC1903420

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

12 in total

1. THE EVOLUTION OF LYSOSOMES IN HYPOXIC LIVER PARENCHYMA AS SEEN WITH THE ELECTRON MICROSCOPE.

Authors: D B CONFER; R J STENGER
Journal: Am J Pathol Date: 1964-10 Impact factor: 4.307

2. [INTRADUCTAL EXPULSION OF FIGURED MATEIAL (CYTOPLASM FRAGMENTS, MITOCHONDRIA) AND GIANT LYSOSOME BODIES IN THE NEONATAL LIVER. INFRAMICROSCOPIC OBSERVATIONS].

Authors: P MALET; L JOYON; J P TURCHINI
Journal: C R Hebd Seances Acad Sci Date: 1964-05-20

6. Liver cell defaecation: an electron-microscope study of the discharge of lysosomal residual bodies into the intercellular space.

Authors: J F Kerr
Journal: J Pathol Date: 1970-02 Impact factor: 7.996

7. Iron metabolism and cell membranes. I. Relation between ferritin and hemosiderin in bile and biliary excretion of lysosome contents.

Authors: W D Bradford; J G Elchlepp; A U Arstila; B F Trump; T D Kinney
Journal: Am J Pathol Date: 1969-08 Impact factor: 4.307

8. Observations on the subcellular organization of hepatic parenchymal cells. II. Evolution of reversible alterations induced by hypoxia.

Authors: W H Glinsmann; J L Ericsson
Journal: Lab Invest Date: 1966-04 Impact factor: 5.662

9. Observations on the ultrastructure and acid phosphatase activity of the cytoplasmic bodies in rat kidney proximal tubule cells. With a comment on their classification.

Authors: A B Maunsbach
Journal: J Ultrastruct Res Date: 1966-10

3. The epithelium covering Peyer's patches in young milk-fed calves. An ultrastructural and enzyme histochemical investigation.

Authors: T Landsverk
Journal: Acta Vet Scand Date: 1981 Impact factor: 1.695

4. The effect of prostaglandins on experimental storage disease in rats.

Authors: K Joh; U N Riede; H P Zahradnik
Journal: J Exp Pathol (Oxford) Date: 1990-04

5. Gut contents, digestive half-lives and feeding state prediction in the soil predatory mite Pergamasus longicornis (Mesostigmata: Parasitidae).

Authors: Clive E Bowman
Journal: Exp Appl Acarol Date: 2017-09-01 Impact factor: 2.132

5 in total

Exocytosis of residual bodies in a lysosomal storage disease.

1. THE EVOLUTION OF LYSOSOMES IN HYPOXIC LIVER PARENCHYMA AS SEEN WITH THE ELECTRON MICROSCOPE.

2. [INTRADUCTAL EXPULSION OF FIGURED MATEIAL (CYTOPLASM FRAGMENTS, MITOCHONDRIA) AND GIANT LYSOSOME BODIES IN THE NEONATAL LIVER. INFRAMICROSCOPIC OBSERVATIONS].

3. The Fine Structure of the Parenchymal Cell of the Normal Rat Liver: I. General Observations.

4. Scanning electron microscopy of extrahepatic biliary obstruction.

5. Enzymic activities associated with membranous cytoplasmic bodies and isolated brain lysosomes.