| Literature DB >> 7188643 |
M G Ziegler, B R Brooks, C R Lake, J H Wood, S J Enna.
Abstract
Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.Entities:
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Year: 1980 PMID: 7188643 DOI: 10.1212/wnl.30.1.98
Source DB: PubMed Journal: Neurology ISSN: 0028-3878 Impact factor: 9.910