Literature DB >> 718777

Pressure reversal of general anaesthesia--a multi-site expansion hypothesis.

M J Halsey, B Wardley-Smith, C J Green.   

Abstract

We have quantitated the pressure reversal of continuous i. v. anaesthesia produced in rats by ketamine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism--the multi-site expansion hypothesis.

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Year:  1978        PMID： 718777     DOI： 10.1093/bja/50.11.1091

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  20 in total

1.  Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.

Authors:  Matthew D Krasowski
Journal:  Bull Anesth Hist       Date:  2003-07

2.  Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal.

Authors:  G W Moss; W R Lieb; N P Franks
Journal:  Biophys J       Date:  1991-12       Impact factor: 4.033

3.  Pressure reversal of alphaxalone/alphadolone and methohexitone in tadpoles: evidence for different molecular sites for general anaesthesia.

Authors:  M J Halsey; B Wardley-Smith; S Wood
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

4.  Rectal and brain temperatures in ethanol intoxicated mice.

Authors:  M Bejanian; D A Finn; P J Syapin; R L Alkana
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

5.  Hyperbaric pressure does not affect the analgesia produced by nitrous oxide in the mouse.

Authors:  P J Cohen
Journal:  Can J Anaesth       Date:  1989-01       Impact factor: 5.063

6.  The physiological effects of hydrostatic pressure are not equivalent to those of helium pressure on Rana pipiens.

Authors:  B A Dodson; Z W Furmaniuk; K W Miller
Journal:  J Physiol       Date:  1985-05       Impact factor: 5.182

Review 7.  Mechanisms of anaesthesia: a mystery.

Authors:  S H Roth
Journal:  Can J Anaesth       Date:  1988-05       Impact factor: 5.063

Review 8.  Molecular targets and mechanisms for ethanol action in glycine receptors.

Authors:  Daya I Perkins; James R Trudell; Daniel K Crawford; Ronald L Alkana; Daryl L Davies
Journal:  Pharmacol Ther       Date:  2010-04-23       Impact factor: 12.310

9.  Effects of ketamine and of high pressure on the responses to gamma-aminobutyric acid of the rat superior cervical ganglion in vitro.

Authors:  H J Little
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

10.  The effects of anaesthetics and high pressure on the responses of the rat superior cervical ganglion in vitro.

Authors:  H J Little; D L Thomas
Journal:  J Physiol       Date:  1986-05       Impact factor: 5.182
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