[Antitumor effect of UFT against malignant tumors of maxillary sinus--clinical and biochemical study].

Antitumor effect of UFT against malignant tumors of the maxillary sinus (male 8, female 5) was examined clinically and biochemically. According to the Karnofsky's criteria, the clinical effectiveness was demonstrated as follows; I-B: 1, I-A: 2, 0-C: 1, 0-B: 2, 0-A: 2, 0-0: 4, unknown: 1. While according to a Japanese Criteria for Evaluation of Clinical Effects of Cancer Chemotherapy on Solid Tumors the results were assessed as follows: CR: 1, PR: 3, NC: 3, PD: 5, unknown: 1. Generally side effect was mild and found in four patients. 5-FU levels in tissue specimens of the two patients were determined. 5-FU levels in the tumor tissues were 1.3 and 2.4 times higher than those of the normal tissues, respectively.