Literature DB >> 7182509

Successful treatment of paraquat poisoning: activated charcoal per os and "continuous hemoperfusion".

S Okonek, L S Weilemann, J Majdandzic, H Setyadharma, H J Reinecke, C A Baldamus, J Lohmann, K E Bonzel, T Thon.   

Abstract

Ingestion of paraquat results in an extremely dangerous poisoning. The first aim is to clear the gastrointestinal tract by inducing emesis and performing gastric/gut lavage; as much activated charcoal as possible should be administered per os and as quickly as possible. The best measure to eliminate paraquat from blood and tissue is hemoperfusion with coated activated charcoal; it has to be performed in the sense of "continuous hemoperfusion" about 8 h/d over a period of 2-3 weeks. These measures give a chance to lower the lethality of paraquat poisoning.

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Year:  1982        PMID: 7182509     DOI: 10.3109/15563658208992514

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN: 0731-3810


  9 in total

1.  Emergency medicine: the use of hemoperfusion to treat poisoning and drug overdose.

Authors:  K R Olson
Journal:  West J Med       Date:  1985-03

2.  In vitro study on the inhibitory effect of magnesium cation on paraquat removal by medical cation exchange resin.

Authors:  M Nakamura; S Tanada; T Nakamura; H Keshi; T Kawanishi
Journal:  Bull Environ Contam Toxicol       Date:  1990-08       Impact factor: 2.151

3.  In vitro adsorption removal of paraquat by activated carbon and cation exchange resin.

Authors:  M Kitakouji; T Miyoshi; S Tanada; T Nakamura
Journal:  Bull Environ Contam Toxicol       Date:  1989-06       Impact factor: 2.151

4.  Kinetics of in vitro paraquat removal by cation-exchange resin.

Authors:  S Tanada; T Nakamura; T Miyoshi; M Nakamura; Y Yamada; H Takahashi; H Terada
Journal:  Bull Environ Contam Toxicol       Date:  1988-07       Impact factor: 2.151

5.  Acceleration of paraquat adsorption onto chitosan by the presence of sodium chloride.

Authors:  S Tanada; S Kyotani; T Nakamura; Y Nishioka
Journal:  Bull Environ Contam Toxicol       Date:  1994-03       Impact factor: 2.151

6.  Evaluation of paraquat concentrations in paraquat poisoning.

Authors:  J Ikebuchi
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

Review 7.  Failure of haemoperfusion and haemodialysis to prevent death in paraquat poisoning. A retrospective review of 42 patients.

Authors:  E C Hampson; S M Pond
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Jan-Dec

8.  Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications.

Authors:  Ricardo Jorge Dinis-Oliveira; Paula Guedes de Pinho; Liliana Santos; Helena Teixeira; Teresa Magalhães; Agostinho Santos; Maria de Lourdes Bastos; Fernando Remião; José Alberto Duarte; Félix Carvalho
Journal:  PLoS One       Date:  2009-09-25       Impact factor: 3.240

9.  Toward a comprehensive approach to the collection and analysis of pica substances, with emphasis on geophagic materials.

Authors:  Sera L Young; M Jeffrey Wilson; Dennis Miller; Stephen Hillier
Journal:  PLoS One       Date:  2008-09-05       Impact factor: 3.240

  9 in total

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