Literature DB >> 7181942

Effects of disulfiram on mixed function oxidase system and trace element concentration in the liver of rats.

B Bertram, J Schuhmacher, E Frei, N Frank, M Wiessler.   

Abstract

Disulfiram (DSF), an inhibitor of chemically induced carcinogenesis, and its metabolite diethyldithiocarbamate (DDTC) have been investigated for their influence on trace element distribution and on certain enzymes of the drug metabolizing system in the livers of phenobarbital (PB) treated rats. Both substances diminished the PB induced enzyme response in liver microsomes, DDTC being more effective (-85%) than DSF (-60%). The copper, cobalt and zinc content of the livers of DSF treated animals were increased by factors of 6, 3 and 1.5 respectively as compared to controls, while DDTC treatment had no influence on liver trace element content. A correlation between enzyme inhibition and enhanced trace element uptake of the liver after DSF administration could not be observed. The change of trace element transport into the liver during DSF treatment is discussed.

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Year:  1982        PMID： 7181942     DOI： 10.1016/0006-2952(82)90584-6

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  5 in total

1.  Use of diethyldithiocarbamate as a probe to detect stable intermediates during the decomposition of several mutagenic and nonmutagenic N-nitroso compounds.

Authors:  M Wiessler; A M Tacchi; B L Pool; B Bertram
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

Authors:  J Schuhmacher; H R Scherf; B Bertram; E Frei; H Hauser; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

3.  Influence of a prolonged treatment with disulfiram and D(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats. I. Investigations on the drug metabolizing system.

Authors:  B Bertram; E Frei; H R Scherf; J Schuhmacher; A M Tacchi; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

4.  Effect of ten thiocompounds on rat liver DNA damage induced by a small dose of N-nitrosodimethylamine.

Authors:  G Brambilla; P Carlo; R Finollo
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

5.  Metabolism of, and DNA methylation by, N-nitrosomethylbenzylamine in chicken.

Authors:  W C Tang; P Z Lin; N Frank; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553
  5 in total

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