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Literature DB >> 7180846

The Cincinnati Lipid Research Clinic family study: cultural and biological determinants of lipids and lipoprotein concentrations.

D C Rao, P M Laskarzewski, J A Morrison, P Khoury, K Kelly, R Wette, J Russell, C J Glueck.

Abstract

A general linear model is described here for cultural and biological inheritance of lipids and lipoproteins. This model involves 10 parameters to be estimated from a total of 17 correlations, leaving ample degrees of freedom to test the goodness of fit. The model fits very well to each of the five lipid and lipoprotein variables analyzed here from a Lipid Research Clinic family data set. Both genetic and cultural inheritance are significant for each trait with the single exception that triglyceride levels fail to support genetic inheritance. Under the most parsimonious hypothesis, the genetic heritability (h2) ranges from .194 +/- .092 for triglyceride to .624 +/- .093 for low-density lipoprotein-cholesterol. Cultural heritability ranges from .070 +/- .030 for total cholesterol to .149 +/- .034 for triglyceride.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1982 PMID： 7180846 PMCID： PMC1685687

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

10 in total

1. Parent-offspring and sibling lipid and lipoprotein associations during and after sharing of household environments: the Princeton school district family study.

Authors: J A Morrison; K Kelly; R Horvitz; P Khoury; P M Laskarzewski; M J Mellies; C J Glueck
Journal: Metabolism Date: 1982-02 Impact factor: 8.694

2. Parent-child associations at upper and lower ranges of plasma cholesterol and triglyceride levels.

Authors: J A Morrison; K A Kelly; M J Mellies; I deGroot; C J Glueck
Journal: Pediatrics Date: 1978-10 Impact factor: 7.124

3. Determinants of blood pressure in Japanese-American Families.

Authors: N E Morton; C L Gulbrandsen; D C Rao; G G Rhoads; A Kagan
Journal: Hum Genet Date: 1980-02 Impact factor: 4.132

4. Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study.

Authors: G Heiss; I Tamir; C E Davis; H A Tyroler; B M Rifkand; G Schonfeld; D Jacobs; I D Frantz
Journal: Circulation Date: 1980-02 Impact factor: 29.690

5. Path analysis under generalized assortative mating. I. Theory.

Authors: D C Rao; N E Morton; C R Cloninger
Journal: Genet Res Date: 1979-04 Impact factor: 1.588

6. Genetic and environmental determinants of periodontal disease.

Authors: D C Rao; C S Chung; N E Morton
Journal: Am J Med Genet Date: 1979

7. Behavioral, social, and physiological determinants of lipoprotein concentrations.

Authors: C L Gulbrandsen; N E Morton; G G Rhoads; A Kagan; R Lew
Journal: Soc Biol Date: 1977

8. Determinants of plasma uric acid.

Authors: C L Gulbrandsen; N E Morton; D C Rao; G G Rhoads; A Kagan
Journal: Hum Genet Date: 1979-09 Impact factor: 4.132

9. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.

Authors: J L Goldstein; H G Schrott; W R Hazzard; E L Bierman; A G Motulsky
Journal: J Clin Invest Date: 1973-07 Impact factor: 14.808

10. Cultural and biological determinants of lipoprotein concentrations.

Authors: D C Rao; N E Morton; C L Gulbrandsen; G G Rhoads; A Kagan; S Yee
Journal: Ann Hum Genet Date: 1979-05 Impact factor: 1.670

10 in total

24 in total

1. Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism.

Authors: L Almasy; J E Hixson; D L Rainwater; S Cole; J T Williams; M C Mahaney; J L VandeBerg; M P Stern; J W MacCluer; J Blangero
Journal: Am J Hum Genet Date: 1999-06 Impact factor: 11.025

2. Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment.

Authors: France Gagnon; Gail P Jarvik; Arno G Motulsky; Samir S Deeb; John D Brunzell; Ellen M Wijsman
Journal: Hum Genet Date: 2003-08-29 Impact factor: 4.132

3. Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia.

Authors: Sarinnapha Vasunilashorn; Eileen M Crimmins; Jung Ki Kim; Jeff Winking; Michael Gurven; Hillard Kaplan; Caleb E Finch
Journal: Am J Hum Biol Date: 2010 Nov-Dec Impact factor: 1.937

4. Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.

Authors: France Gagnon; Gail P Jarvik; Michael D Badzioch; Arno G Motulsky; John D Brunzell; Ellen M Wijsman
Journal: Hum Genet Date: 2005-06-16 Impact factor: 4.132

10. Segregation analysis of low levels of high-density lipoprotein cholesterol in the collaborative Lipid Research Clinics Program Family Study.

Authors: K D Bucher; E B Kaplan; K K Namboodiri; C J Glueck; P Laskarzewski; B M Rifkind
Journal: Am J Hum Genet Date: 1987-06 Impact factor: 11.025