| Literature DB >> 7177493 |
T Di Paolo, A Dupont, M Daigle.
Abstract
We investigated the effect of chronic estradiol treatment on dopamine concentrations in 14 discrete brain nuclei of hypophysectomized rats. Estrogen treatment reduced dopamine concentrations in nigrostriatal and mesolimbic dopaminergic systems of hypophysectomized and ovariectomized rats compared to hypophysectomized controls while the opposite was observed in tuberoinfundibular nuclei. However, hypophysectomized rats had significantly higher dopamine concentrations compared to ovariectomized animals is nigrostriatal and mesolimbic nuclei while lower levels were found in tuberoinfundibular structures. Thus, estradiol treatment has an effect on brain dopamine concentrations independently of the pituitary. Furthermore, this steroid treatment corrects the effects produced by hypophysectomy on brain dopamine concentrations.Entities:
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Year: 1982 PMID： 7177493 DOI： 10.1016/0304-3940(82)90310-x
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046