Literature DB >> 7174537

Antibacterial effects of cefroxadine, cephalexin and cephradine in a new in vitro pharmacokinetic model.

P Schneider, W Tosch, M Maurer, O Zak.   

Abstract

A pharmacokinetic model has been developed, by means of which all possible time courses of the concentrations of antibiotics in the plasma of treated individuals can be exactly simulated in vitro without diluting the test organism and affecting the growth curves. Equieffective concentrations in the system corresponded to the plasma concentrations in man produced by cefroxadine in a single oral dose of 250 mg and cephalexin and cephradine in a single oral dose of 500 mg.

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Year:  1982        PMID: 7174537     DOI: 10.7164/antibiotics.35.843

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  5 in total

1.  Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model.

Authors:  A A Firsov; V M Chernykh; S M Navashin
Journal:  Antimicrob Agents Chemother       Date:  1990-07       Impact factor: 5.191

2.  Pharmacodynamic effects of sub-MICs of benzylpenicillin against Streptococcus pyogenes in a newly developed in vitro kinetic model.

Authors:  E Löwdin; I Odenholt; S Bengtsson; O Cars
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

3.  Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model.

Authors:  C Rustige; B Wiedemann
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

4.  Antipseudomonal activity of simulated infusions of gentamicin alone or with piperacillin assessed by serum bactericidal rate and area under the killing curve.

Authors:  J E Tisdale; M T Pasko; J M Mylotte
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

5.  Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model.

Authors:  J Blaser; B B Stone; S H Zinner
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

  5 in total

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