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Literature DB >> 7173862

Similar chromosomal abnormalities in several retinoblastomas.

L E Kusnetsova, E L Prigogina, H E Pogosianz, B M Belkina.

Abstract

The study of banded chromosomes of nine sporadic unilateral retinoblastomas revealed near diploid karyotypes with multiple numerical and (or) structural abnormalities in all tumors. An identical marker i(6p) was noted in cells of the modal class of six retinoblastomas. Extra copies of the short arm of chromosome 6 were observed in seven tumors: +i(6p) in 6 and +6q-in one. Less regular but repeated findings were a loss of one sex chromosome, and markers 1p+ and 17q+. The structure of these markers was not identical in different tumors. Abnormalities of chromosome 13 were not observed in tumor cells, nor in blood lymphocytes stimulated by PHA.

Entities: Disease Gene

Mesh：

Year: 1982 PMID： 7173862 DOI： 10.1007/bf00296442

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

1. High resolution of human chromosomes.

Authors: J J Yunis
Journal: Science Date: 1976-03-26 Impact factor: 47.728

2. Retinoblastoma and long arm delection of chromosome 13. Attempts to define the deleted segment.

Authors: E Orye; M J Delbeke; B Vandenabeele
Journal: Clin Genet Date: 1974 Impact factor: 4.438

3. Characterization of a new continuous cell line derived from a human retinoblastoma.

Authors: R C McFall; T W Sery; M Makadon
Journal: Cancer Res Date: 1977-04 Impact factor: 12.701

4. Retinoblastoma: host resistance and 13q- chromosomal deletion.

Authors: E Matsunaga
Journal: Hum Genet Date: 1980 Impact factor: 4.132

5. Chromosome 1 in 26 carcinomas of the cervix uteri: structural and numerical changes.

Authors: N B Atkin; M C Baker
Journal: Cancer Date: 1979-08 Impact factor: 6.860

6. Retinoblastoma and subband deletion of chromosome 13.

Authors: J J Yunis; N Ramsay
Journal: Am J Dis Child Date: 1978-02

7. An international system for human cytogenetic nomenclature (1978) ISCN (1978). Report of the Standing Commitee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1978

6. Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization.

Authors: J Squire; R A Phillips; S Boyce; R Godbout; B Rogers; B L Gallie
Journal: Hum Genet Date: 1984 Impact factor: 4.132

Review 7. Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers.

Authors: H J Evans; J Prosser
Journal: Environ Health Perspect Date: 1992-11 Impact factor: 9.031

7 in total

Similar chromosomal abnormalities in several retinoblastomas.

1. High resolution of human chromosomes.

2. Retinoblastoma and long arm delection of chromosome 13. Attempts to define the deleted segment.

3. Characterization of a new continuous cell line derived from a human retinoblastoma.

4. Retinoblastoma: host resistance and 13q- chromosomal deletion.

5. Chromosome 1 in 26 carcinomas of the cervix uteri: structural and numerical changes.

6. Retinoblastoma and subband deletion of chromosome 13.

7. An international system for human cytogenetic nomenclature (1978) ISCN (1978). Report of the Standing Commitee on Human Cytogenetic Nomenclature.

8. Homogeneously staining region in a retinoblastoma cell line: relevance to tumor initiation and progression.

9. Chromosome 14q+ in a retinoblastoma.

10. A deleted chromosome no. 13 in human retinoblastoma cells: relevance to tumorigenesis.

1. Fluctuation of a clone 46,XX,i(7q) in bone marrow in a Fanconi anaemia.

2. Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma.

3. Cytogenetics and cytology of retinoblastomas.

4. A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma.

5. p107 is a suppressor of retinoblastoma development in pRb-deficient mice.

6. Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization.

Review 7. Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers.