Literature DB >> 7173598

Kinetics of the distribution and elimination of chloroquine in the rat.

S A Adelusi, L A Salako.   

Abstract

1. The distribution of chloroquine was studied in the tissues and blood of rat. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells. 3. The tissue to plasma concentration ratio increased with time up to 144th hr for some tissues while this ratio was still increasing at the 168th hr for other tissues. 4. The values of beta estimated for the tissues were lower than those for plasma or red blood cells. The values differed from one another for the tissues but were similar for plasma and red blood cells.

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Year:  1982        PMID: 7173598     DOI: 10.1016/0306-3623(82)90110-0

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN: 0306-3623


  16 in total

1.  The disposition of chloroquine in healthy Nigerians after single intravenous and oral doses.

Authors:  O Walker; L A Salako; G Alván; O Ericsson; F Sjöqvist
Journal:  Br J Clin Pharmacol       Date:  1987-03       Impact factor: 4.335

2.  Failure to detect amodiaquine in the blood after oral administration.

Authors:  L A Salako; O R Idowu
Journal:  Br J Clin Pharmacol       Date:  1985-10       Impact factor: 4.335

3.  Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria.

Authors:  O Walker; A H Dawodu; A A Adeyokunnu; L A Salako; G Alvan
Journal:  Br J Clin Pharmacol       Date:  1983-12       Impact factor: 4.335

4.  Physiologically Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Human.

Authors:  Xin Liu; William J Jusko
Journal:  J Pharmacol Exp Ther       Date:  2020-12-04       Impact factor: 4.030

5.  Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients.

Authors:  Xueting Yao; Xiaoyu Yan; Xiaohan Wang; Ting Cai; Shun Zhang; Cheng Cui; Xiaoxu Wang; Zhe Hou; Qi Liu; Haiyan Li; Jing Lin; Zi Xiong; Dongyang Liu
Journal:  Eur J Clin Pharmacol       Date:  2020-11-13       Impact factor: 2.953

Review 6.  Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties.

Authors:  Cornelis Smit; Mariska Y M Peeters; John N van den Anker; Catherijne A J Knibbe
Journal:  Clin Pharmacokinet       Date:  2020-06       Impact factor: 6.447

7.  Authors' response.

Authors:  Pranab Chatterjee; Tanu Anand; Kh Jitenkumar Singh; Reeta Rasaily; Ravinder Singh; Santasabuj Das; Harpreet Singh; Ira Praharaj; Raman R Gangakhedkar; Balram Bhargava; Samiran Panda
Journal:  Indian J Med Res       Date:  2020 Jul & Aug       Impact factor: 2.375

8.  Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study.

Authors:  Azrin N Abd-Rahman; Louise Marquart; Nathalie Gobeau; Anne Kümmel; Julie A Simpson; Stephan Chalon; Jörg J Möhrle; James S McCarthy
Journal:  Clin Pharmacol Ther       Date:  2020-07-02       Impact factor: 6.903

9.  Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling.

Authors:  Karen Rowland Yeo; Mian Zhang; Xian Pan; Alice Ban Ke; Hannah M Jones; David Wesche; Lisa M Almond
Journal:  Clin Pharmacol Ther       Date:  2020-07-16       Impact factor: 6.903

10.  Hydroxychloroquine, dermatology, and SARS-CoV-2: Updating an old association.

Authors:  Federico Diotallevi; Anna Campanati; Giulia Radi; Michele M Luchetti; Devis Benfaremo; Corrado Tagliati; Oriana Simonetti; Annamaria Offidani
Journal:  J Med Virol       Date:  2020-07-28       Impact factor: 20.693

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