Literature DB >> 7173269

Investigations on the in vitro dose-related metabolism of indomethacin in four laboratory species.

J S Rowe, J E Carless.   

Abstract

The influence of dose on the in vitro metabolism of indomethacin has been investigated in four laboratory species (rat, rabbit, guinea pig, hamster). It was found that in the rat and guinea pig the ratio of deacylated to demethylated metabolites was dependent on the substrate concentration of indomethacin, whereas in the rabbit the ratio remained constant in the dosage range investigated (1-10 mumoles). No demethylated product was found in the hamster but a high level of activity of the deacylase enzyme was observed. These findings may help to explain species-dependent toxicity.

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Year:  1982        PMID： 7173269     DOI： 10.1007/BF03189561

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  16 in total

1.  THE METABOLITES OF INDOMETHACIN, A NEW ANTI-INFLAMMATORY DRUG.

Authors:  R E HARMAN; M A MEISINGER; G E DAVIS; F A KUEHL
Journal:  J Pharmacol Exp Ther       Date:  1964-02       Impact factor: 4.030

2.  CLINICAL TEST OF INDOMETHACIN.

Authors:  L J MICHOTTE; M WAUTERS
Journal:  Acta Rheumatol Scand       Date:  1964

3.  A CLINICAL TRIAL OF INDOMETHACIN IN RHEUMATOID ARTHRITIS.

Authors:  A M KATZ; C M PEARSON; J M KENNEDY
Journal:  Clin Pharmacol Ther       Date:  1965 Jan-Feb       Impact factor: 6.875

4.  INDOMETHACIN AND PEPTIC ULCER.

Authors:  O LOEVGREN; E ALLANDER
Journal:  Br Med J       Date:  1965-04-10

5.  The metabolism of indomethacin in man.

Authors:  D E Duggan; A F Hogans; K C Kwan; F G McMahon
Journal:  J Pharmacol Exp Ther       Date:  1972-06       Impact factor: 4.030

6.  Species differences in susceptibility to the gastro-ulcerogenic action of anti-inflammatory agents.

Authors:  G Wilhelmi
Journal:  Pharmacology       Date:  1974       Impact factor: 2.547

7.  Indomethacin in rheumatoid arthritis. A comparative objective evaluation with adrenocorticosteroids.

Authors:  C J Smyth
Journal:  Arthritis Rheum       Date:  1965-10

8.  Role of the entero-hepatic cycle of indomethacin on its metabolism, distribution in tissues and its excretion by rats, dogs and monkeys.

Authors:  D W Yesair; M Callahan; L Remington; C J Kensler
Journal:  Biochem Pharmacol       Date:  1970-05       Impact factor: 5.858

9.  Enterohepatic circulation of indomethacin and its role in intestinal irritation.

Authors:  D E Duggan; K F Hooke; R M Noll; K C Kwan
Journal:  Biochem Pharmacol       Date:  1975-10-01       Impact factor: 5.858

10.  Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids.

Authors:  W Lippmann
Journal:  Prostaglandins       Date:  1974-08-10
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