Literature DB >> 7172024

Dihydroxytryptamines as tools to study the neurobiology of serotonin.

H G Baumgarten, H P Klemm, J Sievers, H G Schlossberger.   

Abstract

The neurotoxins 5,6- and 5,7-dihydroxytryptamine are accepted tools for "chemical degeneration" of serotonergic (5-HT) axons in the CNS (for reviews, see [11, 12, 15, 20] ). Optimum application of these substances requires knowledge of their chemical properties, disposition in the biophase and mechanism of action. Current knowledge and concepts on this issue are described and results of recent studies utilizing 5,7-DHT uptake as a tool for localizing 5-HT neurons neuroanatomically are reviewed.

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Year:  1982        PMID： 7172024     DOI： 10.1016/0361-9230(82)90128-9

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  7 in total

1.  Lesioning of serotoninergic and noradrenergic nerve fibres of the rat brain does not decrease binding of 3H-clonidine and 3H-rauwolscine to cortical membranes.

Authors:  G Gross; M Göthert; U Glapa; G Engel; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-01       Impact factor: 3.000

2.  Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine.

Authors:  Rani K Vasudeva; Alexander R Hobby; Lynn G Kirby
Journal:  Behav Brain Res       Date:  2015-06-11       Impact factor: 3.332

Review 3.  Serotonin neurotoxins--past and present.

Authors:  H G Baumgarten; L Lachenmayer
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

4.  A topography and ultrastructural characterization of in vivo 5,7-dihydroxytryptamine-labeled serotonin-containing neurons in the central nervous system of Aplysia californica.

Authors:  L Hernádi; K S Rózsa; B Jahan-Parwar; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1992-08       Impact factor: 5.046

5.  Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala.

Authors:  Adam L Halberstadt; Carey D Balaban
Journal:  J Chem Neuroanat       Date:  2008-03-08       Impact factor: 3.052

6.  Selective anterograde tracing of the individual serotonergic and nonserotonergic components of the dorsal raphe nucleus projection to the vestibular nuclei.

Authors:  A L Halberstadt; C D Balaban
Journal:  Neuroscience       Date:  2007-05-15       Impact factor: 3.590

7.  Depletion of brain serotonin by 5,7-dihydroxytryptamine alters the response to amphetamine and the habituation of locomotor activity in rats.

Authors:  P F Gately; S L Poon; D S Segal; M A Geyer
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530
  7 in total

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