[Effect of liposomes of different size, composition and charge on the colony-forming ability of cells].

Influence of liposomes on the colony-forming ability of LL cells was studied. Inhibition of cell proliferative activity was revealed as a result of using multilamellar and unilamellar neutral, positively and negatively charged liposomes at similar lipid concentrations (0.2-0.3 mumol/ml). Viability of the cells evaluated from eosine staining was 90-95% immediately after liposomal treatment as was the case at all the cultivation time-points similar to control. Quantitation of the cells during cultivation after liposomal treatment showed that suppression of the proliferation occurs at the first day after the cells-vesicule contact.