[Morphological characteristics of healing of extensive purulent wounds during treatment in the controlled bacteria-free environment].

Histological, histochemical and cytological techniques were used to examine the healing of extensive purulent wounds treated in a controlled abacterial medium (an open-type method of treatment). Biopsies were taken from 25 patients and explored throughout the entire treatment course (from 1 to 26 days). It was shown that the treatment brought about acceleration of wound purification and reparation. Wound tissues manifested a drastic lowering of the content of microflora and polymorphonuclear neutrophils. On days 3-5 of the treatment in the wound cavity there appeared close-grained granulations containing mature macrophages with high phagocytic activity and proliferating fibroblasts. On days 7-10 there emerged mature granulation tissue well fit for autodermoplasty.