Literature DB >> 7169269

Radical scavengers and the stability of 99mTc-radiopharmaceuticals.

R Berger.   

Abstract

It was found that compounds, such as ene-1,2-diols, diphenyl derivatives, and certain oxidants, are suited to prevent decomposition of 99mTc-radiopharmaceuticals. For effective stabilization of 99mTc(Sn)-DTPA different radioactive concentrations of 99mTcO-4 solution require different concentrations of stabilizers. As a possible reason for the decomposition of 99mTc-radiopharmaceuticals radicals are discussed. Superoxide anion or hydroperoxyl radicals are especially taken into consideration.

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Year:  1982        PMID: 7169269     DOI: 10.1016/0020-708x(82)90165-x

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN: 0020-708X


  2 in total

1.  A method for stabilising technetium-99m exametazime prepared from a commercial kit.

Authors:  P S Weisner; G R Bower; L A Dollimore; A M Forster; B Higley; A E Storey
Journal:  Eur J Nucl Med       Date:  1993-08

2.  Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tracer in focal cerebral ischaemia.

Authors:  G Gartshore; P Bannan; J Patterson; B Higley; J McCulloch
Journal:  Eur J Nucl Med       Date:  1994-09
  2 in total

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