The selectivity of the anorectic effect of satietin. III. The ineffectiveness of satietin on metabolic rate, body temperature and blood pressure.

Satietin, a recently discovered endogenous anorectic substance, prepared from human serum was found to inhibit food intake in a very selective manner. As the hypothalamic satiety center was proposed to be the site of effect of satietin, its effect on other physiological processes (metabolic rate, body temperature, blood pressure) controlled by the hypothalamus was investigated. Satietin did not change the metabolic rate of rats, had no influence on the body temperature and did not affect blood pressure. For sake of comparison the effects of endogenous peptides, like calcitonin, known to inhibit food intake and the representatives of the two main classes of anorectics, amphetamine and fenfluramine, were also studied.