Literature DB >> 7163736

Synthesis of underpolymerized hyaluronic acid by fibroblasts cultured from rheumatoid and non-rheumatoid synovitis.

E Vuorio, S Einola, S Hakkarainen, R Penttinen.   

Abstract

Fibroblast cultures were started from synovial tissue of normal controls and patients with seronegative and seropositive rheumatoid arthritis, juvenile rheumatoid arthritis and chronic non-rheumatoid synovitis. Glycosaminoglycan synthesis of the cultures was studied by metabolic labeling with 3H-glucosamine. Molecular weight of hyaluronic acid produced and secreted into culture medium by these fibroblast strains was studied by gel filtration in a Sepharose 2 B column. All fibroblast strains from joints with active inflammation produced hyaluronate with decreased molecular weight. The synthesis of underpolymerized hyaluronate thus appears to be a property of activated synovial fibroblasts common to rheumatoid and non-rheumatoid inflammation.

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Year:  1982        PMID： 7163736     DOI： 10.1007/bf00541160

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  11 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  A rapid method for separation and assay of radiolabeled mucopolysaccharides from cell culture medium.

Authors:  H Saarni; M Tammi
Journal:  Anal Biochem       Date:  1977-07       Impact factor: 3.365

3.  Rheumatoid disease in cultured human synovial cells. A biochemical study on glycosaminoglycans, proteins and plasma membranes of synovial fibroblasts in culture.

Authors:  E Vuorio
Journal:  Scand J Clin Lab Invest Suppl       Date:  1977

4.  Physiological function of connective tissue polysaccharides.

Authors:  W D Comper; T C Laurent
Journal:  Physiol Rev       Date:  1978-01       Impact factor: 37.312

5.  Connective tissue activation. 3. Observations on the mechanism of action of connective tissue activating peptide.

Authors:  C W Castor
Journal:  J Lab Clin Med       Date:  1972-02

6.  The characterisation and function of the polysaccharidases of human synovial fluid in rheumatoid and osteoarthritis.

Authors:  R W Stephens; P Ghosh; T K Taylor
Journal:  Biochim Biophys Acta       Date:  1975-07-14

7.  Effects of sodium aurothiomalate on hyaluronic acid synthesis in normal and rheumatoid synovial fibroblast cultures.

Authors:  E Vuorio; I Takala; K Pulkki; S Einola
Journal:  Scand J Rheumatol       Date:  1979       Impact factor: 3.641

8.  Abnormalities of connective tissue cells cultured from patients with rheumatoid arthritis. I. Relative unresponsiveness of rheumatoid synovial cells to hydrocortisone.

Authors:  C W Castor; E L Dorstewitz
Journal:  J Lab Clin Med       Date:  1966-08

9.  Kinetics of mucopolysaccharide and glycoprotein synthesis by chick embryo chondrocytes. Effect of D-glucose concentration in the culture medium.

Authors:  J J Kim; H E Conrad
Journal:  J Biol Chem       Date:  1976-10-25       Impact factor: 5.157

10.  The effect of cell density on net rates of glycosaminoglycan synthesis and secretion by cultured rat fibroblasts.

Authors:  L Hronowski; T P Anastassiades
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157
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  18 in total

Review 1.  Hyaluronate in rheumatology and orthopaedics: is there a role?

Authors:  R K Strachan; P Smith; D L Gardner
Journal:  Ann Rheum Dis       Date:  1990-11       Impact factor: 19.103

2.  Size selectivity of hyaluronan molecular sieving by extracellular matrix in rabbit synovial joints.

Authors:  S Sabaratnam; V Arunan; P J Coleman; R M Mason; J R Levick
Journal:  J Physiol       Date:  2005-06-16       Impact factor: 5.182

3.  Hyaluronan production in human rheumatoid fibroblastic synovial lining cells is increased by interleukin 1 beta but inhibited by transforming growth factor beta 1.

Authors:  M Kawakami; K Suzuki; Y Matsuki; T Ishizuka; T Hidaka; T Konishi; M Matsumoto; K Kataharada; H Nakamura
Journal:  Ann Rheum Dis       Date:  1998-10       Impact factor: 19.103

Review 4.  Viscosupplementation treatment of arthritis pain.

Authors:  Michael Benke; Benjamin Shaffer
Journal:  Curr Pain Headache Rep       Date:  2009-12

5.  Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.

Authors:  Aya Nagaoka; Hiroyuki Yoshida; Sachiko Nakamura; Tomohiko Morikawa; Keigo Kawabata; Masaki Kobayashi; Shingo Sakai; Yoshito Takahashi; Yasunori Okada; Shintaro Inoue
Journal:  J Biol Chem       Date:  2015-10-30       Impact factor: 5.157

6.  Dietary supplements as disease-modifying treatments in osteoarthritis: a critical appraisal.

Authors:  Philip J Gregory; Chris Fellner
Journal:  P T       Date:  2014-06

7.  In vitro model of hyaluronan synthase gene expression associated with lipopolysaccharide-induced inflammation in SW982 cell line.

Authors:  Nawarat Viriyakhasem; Siriprapa Khuajan; Prachya Kongtawelert; Ampai Panthong; Siriwan Ongchai; Vichai Reutrakul
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-06-17       Impact factor: 2.416

8.  Hyaluronic acid production in vitro by synovial lining cells from normal and rheumatoid joints.

Authors:  I M Dahl; G Husby
Journal:  Ann Rheum Dis       Date:  1985-10       Impact factor: 19.103

9.  Altered glycosaminoglycan production in cultured osteogenesis-imperfecta skin fibroblasts.

Authors:  H Turakainen
Journal:  Biochem J       Date:  1983-07-01       Impact factor: 3.857

10.  The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment.

Authors:  M M Smith; P Ghosh
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631
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