| Literature DB >> 7162350 |
N L Ostrowski, C B Hatfield, A R Caggiula.
Abstract
Intravenous (IV) administration of 10 ug/kg of morphine sulfate increased the firing rate of Type A dopamine neurons but decreased the extracellular activity of Type B dopamine cells in the substantia nigra pars compacta and ventral tegmental area of anesthetized male rats. The morphine-produced increase in Type A cells was antagonized by 0.10 mg/kg of naloxone, whereas the suppression of B cells was blocked only by pretreatment with 5.0 mg/kg of naloxone. This same low dose of morphine (IV) also produced increased locomotor activity in awake male rats within 10 min of administration.Entities:
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Year: 1982 PMID： 7162350 DOI： 10.1016/0024-3205(82)90153-9
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037