| Literature DB >> 7162139 |
K G Verebey, A DePace, S J Mulé, M Kanzler, J H Jaffe.
Abstract
Published gas-liquid chromatographic (GLC) methods for the determination of nicotine and cotinine have proved impractical for the analysis of a large number of clinical samples. Significant improvements over other methods have been achieved, being low sample volume (0.5 mL plasma), rapid two-step extraction from plasma, no evaporation step, and good separation. The lower limits of sensitivity for nicotine and cotinine were 1 and 5 ng/mL, respectively. The method was validated by the analysis of plasma samples from cigarette-smoking volunteers. The method described permits the quick, routine determination of nicotine and cotinine in a large number of samples.Entities:
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Year: 1982 PMID： 7162139 DOI： 10.1093/jat/6.6.294
Source DB: PubMed Journal: J Anal Toxicol ISSN： 0146-4760 Impact factor: 3.367