| Literature DB >> 7161613 |
Y de Smet, M Ruberg, M Serdaru, B Dubois, F Lhermitte, Y Agid.
Abstract
Among a population of 75 hospitalised Parkinsonian subjects, confusional states were observed in 46% of demented patients not receiving anticholinergic drugs and in 93% of demented patients under anticholinergic therapy. The sensitivity of demented Parkinsonians to anticholinergic drugs can be attributed to a cholinergic deficiency which has been detected in the cortex and hippocampus of Parkinsonian patients post-mortem. The observations suggest that anticholinergic medication should be avoided in Parkinsonians with intellectual impairment.Entities:
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Year: 1982 PMID： 7161613 PMCID： PMC491705 DOI： 10.1136/jnnp.45.12.1161
Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154