Literature DB >> 7160599

Effects of intraduodenal feeding of a branched-chain amino acid-rich solution on ammonia-induced encephalopathy in liver-injured rats.

S Hayashi, A Watanabe, T Shiota, T Obata, N Takei, T Sakata, H Nagashima.   

Abstract

A preventive effect of intraduodenal prefeeding of a branched-chain amino acid (BCAA)-rich solution on ammonia-induced encephalopathy was investigated with carbon tetrachloride CC14-injured rats with the elevated levels of blood ammonia. Five out of six cirrhotic rats, to which an electrolyte solution alone was preinfused for 24 hours, fell into coma following ammonia acetate injection and two comatose rats died. However, no cirrhotic rats preinfused with a BCAA-rich solution died and only two out of the six showed coma with complete recovery. The similar preventive effect could not be observed in rats with acute liver injury.

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Year:  1982        PMID： 7160599     DOI： 10.1007/bf02779131

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  8 in total

1.  An animal model of fulminant hepatic failure in the rat.

Authors:  A Watanabe; T Higashi; H Nagashima
Journal:  Acta Med Okayama       Date:  1979-12       Impact factor: 0.892

2.  The syndrome of impending hepatic coma in patients with cirrhosis of the liver given certain nitrogenous substances.

Authors:  G B PHILLIPS; R SCHWARTZ; G J GABUZDA; C S DAVIDSON
Journal:  N Engl J Med       Date:  1952-08-14       Impact factor: 91.245

3.  Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.

Authors:  J E Fischer; J H James
Journal:  Am J Surg       Date:  1972-02       Impact factor: 2.565

4.  Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma.

Authors:  L Zieve; W M Doizaki; J Zieve
Journal:  J Lab Clin Med       Date:  1974-01

5.  Methanethiol and fatty acids depress urea synthesis by the isolated perfused rat liver.

Authors:  R F Derr; L Zieve
Journal:  J Lab Clin Med       Date:  1982-10

6.  Methionine-induced hepatic coma in dogs.

Authors:  G E Merino; T Jetzer; W M Doizaki; J S Najarian
Journal:  Am J Surg       Date:  1975-07       Impact factor: 2.565

7.  The effect of normalization of plasma amino acids on hepatic encephalopathy in man.

Authors:  J E Fischer; H M Rosen; A M Ebeid; J H James; J M Keane; P B Soeters
Journal:  Surgery       Date:  1976-07       Impact factor: 3.982

8.  Impaired metabolism of methionine in severe liver diseases. II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathy.

Authors:  T Higashi
Journal:  Gastroenterol Jpn       Date:  1982-04
  8 in total
  1 in total

1.  Effect of oral branched chain amino acids on behavior and brain serotonin metabolism in portacaval shunted rats.

Authors:  F Bengtsson; A Nobin; B Falck; F H Gage; B Jeppsson
Journal:  World J Surg       Date:  1988-04       Impact factor: 3.352
  1 in total

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