Literature DB >> 7159602

The effects of succinylacetone (4,6-dioxoheptanoic acid) on delta-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells.

N Schoenfeld, Y Greenblat, O Epstein, A Atsmon.   

Abstract

Succinylacetone was shown to inhibit aminolevulinate dehydratase (5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24) to reduce cellular heme and porphyrins and to induce delta-aminolevulinate synthase (succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37) in monolayers of chick embryo liver cells. Marked synergistic effects on delta-aminolevulinate synthase activity were obtained by combining succinylacetone with levulinate and porphyrogenic drugs. The time course of delta-aminolevulinate synthase activity showed a delayed synergistic response.

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Year:  1982        PMID： 7159602     DOI： 10.1016/0167-4889(82)90096-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  A heme-protein-based oxygen-sensing mechanism controls the expression and suppression of multiple proteins in anoxia-tolerant turtle hepatocytes.

Authors:  S C Land; P W Hochachka
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-01       Impact factor: 11.205

2.  Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448.

Authors:  P R Sinclair; W J Bement; H L Bonkovsky; J F Sinclair
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

3.  Hereditary tyrosinaemia type I: a long-term study of the relationship between the urinary excretions of succinylacetone and delta-aminolevulinic acid.

Authors:  H Schierbeek; G J Beukeveld; H van Faassen; F J van Spronsen; K Bijsterveld; E E Venekamp-Hoolsema; B G Wolthers; G P Smit
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

4.  Induction of 5-aminolaevulinate synthase by two- to five-carbon alcohols in cultured chick-embryo hepatocytes. Relationship to induction of cytochrome P-450.

Authors:  J F Sinclair; L M Zaitlin; E L Smith; S K Howell; H L Bonkovsky; P R Sinclair
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857
  4 in total

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