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Literature DB >> 7155205

Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study.

Abstract

N-trifluoroacetyl phosphatidyl ethanolamine was found as an intermediate of biotransformation of halothane after intense in vivo exposure of non-induced and phenobarbital induced rabbits. The metabolite has been identified in detergent treated liver microsomes by 31P-NMR-spectroscopy and in microsomal lipid extracts by 19F-NMR- and 1H-NMR-spectroscopy as well as by thin layer chromatography. The same exposure changed phospholipid composition of liver microsomal membranes: most prominent was a substantial decrease of the ratio of phosphatidyl ethanolamines to phosphatidylcholines.

Entities: Chemical Species

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Year: 1982 PMID： 7155205 DOI： 10.1007/bf00505492

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

11 in total

1. A rapid method of total lipid extraction and purification.

Authors: E G BLIGH; W J DYER
Journal: Can J Biochem Physiol Date: 1959-08

2. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Antibody formation in response to liposomal model membranes sensitized with N-substituted phosphatidylethanolamine derivatives.

Authors: K Uemura; R A Nicolotti; H R Six; S C Kinsky
Journal: Biochemistry Date: 1974-04-09 Impact factor: 3.162

5. Correspondence: the biotransformation of halothane.

Authors: A Stier
Journal: Anesthesiology Date: 1968 Mar-Apr Impact factor: 7.892

6. Urinary metabolites of halothane in man.

Authors: E N Cohen; J R Trudell; H N Edmunds; E Watson
Journal: Anesthesiology Date: 1975-10 Impact factor: 7.892

7. 1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.

Authors: J R Trudell; A Trevor
Journal: Biochem Biophys Res Commun Date: 1981-09-16 Impact factor: 3.575

Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study.

1. A rapid method of total lipid extraction and purification.

2. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

3. Protein measurement with the Folin phenol reagent.

4. Antibody formation in response to liposomal model membranes sensitized with N-substituted phosphatidylethanolamine derivatives.

5. Correspondence: the biotransformation of halothane.

6. Urinary metabolites of halothane in man.

7. 1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.

8. Preparation of liver microsomes with high recovery of endoplasmic reticulum and a low grade of contamination.

9. A universal reagent for phospholipid analysis.

10. Phosphorus NMR analysis of phospholipids in detergents.

1. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

Review 2. Toxicology of chlorofluorocarbon replacements.