Literature DB >> 7155200

Effects of intrapallidal drugs on hyperactivity induced by nucleus accumbens dopamine receptor stimulation.

P Slater, D A Longman, S L Dickinson.   

Abstract

The effect of manipulating globus pallidus (GP) transmitters on the locomotor hyperactivity induced by administration of the dopamine agonist ADTN in the nucleus accumbens was investigated in rats with permanent intracerebral cannulae. Hyperactivity was antagonized by the GABA agonists muscimol and baclofen and the GABA antagonist bicuculline. Atropine, ADTN and ethylketazocine in GP had no effects on the response. Both morphine and the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine prevented the hyperactivity. The findings emphasize the role of GP GABA in the NA-induced hyperactivity and provide information about the functions of some other GP transmitters.

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Year:  1982        PMID： 7155200     DOI： 10.1007/bf00505486

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  36 in total

1.  Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

Authors:  G J Balcom; R H Lenox; J L Meyerhoff
Journal:  J Neurochem       Date:  1975-04       Impact factor: 5.372

2.  A note on the connections and development of the nucleus accumbens.

Authors:  L W Swanson; W M Cwan
Journal:  Brain Res       Date:  1975-07-11       Impact factor: 3.252

3.  Serotonin content of the brain stem nuclei in the rat.

Authors:  M Palkovits; M Brownstein; J M Saavedra
Journal:  Brain Res       Date:  1974-11-15       Impact factor: 3.252

4.  Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat.

Authors:  A J Pijnenburg; W M Honig; J M Van Rossum
Journal:  Psychopharmacologia       Date:  1975

5.  The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.

Authors:  E M Joyce; G F Koob; R Strecker; S D Iversen; F E Bloom
Journal:  Brain Res       Date:  1981-09-28       Impact factor: 3.252

6.  The distribution and origin of glutamate decarboxylase and choline acetyltransferase in ventral pallidum and other basal forebrain regions.

Authors:  I Walaas; F Fonnum
Journal:  Brain Res       Date:  1979-11-16       Impact factor: 3.252

7.  Role of globus pallidus GABA and opiate receptors in apomorphine circling in nigro-striatal lesioned rats.

Authors:  P Slater
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-04       Impact factor: 3.000

8.  Serotonin neurons of the midbrain raphe: ascending projections.

Authors:  R Y Moore; A E Halaris; B E Jones
Journal:  J Comp Neurol       Date:  1978-08-01       Impact factor: 3.215

9.  Effect of lesioning dopamine, noradrenaline and 5-hydroxytryptamine pathways on tremorine-induced tremor and rigidity.

Authors:  S L Dickinson; P Slater
Journal:  Neuropharmacology       Date:  1982-08       Impact factor: 5.250

10.  Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.

Authors:  H W Kosterlitz; S J Paterson; L E Robson
Journal:  Br J Pharmacol       Date:  1981-08       Impact factor: 8.739
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  3 in total

1.  Mesolimbic dopamine and its control of locomotor activity in rats: differences in pharmacology and light/dark periodicity between the olfactory tubercle and the nucleus accumbens.

Authors:  A R Cools
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  A lesioning and 2-deoxyglucose study of the hyperactivity produced by an intra-accumbens dopamine agonist.

Authors:  S Patel; P Slater; A R Crossman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-12       Impact factor: 3.000

3.  Changes in limb tone produced by regional injections of opiates into rat brain.

Authors:  P Slater; D A Starkie
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-01       Impact factor: 3.000
  3 in total

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