Literature DB >> 7154864

A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behavior in male rats.

G Gonzales, L Mendoza, J Ruiz, J Torrejón.   

Abstract

In the male rat, subcutaneous injections for 7 days of 20 mg/Kg B.W./day of 5-hydroxytryptamine creatinin sulphate (5-HT), caused remarkable inhibitory effects on sexual behavior. The mount and intromission latencies were increased in rats treated with 5-HT, whereas ejaculation latency in the few rats treated with 5-HT that it achieved, was similar to that obtained in control rats. The mount and intromission frequencies were decreased in the rats treated with 5-HT. The mean inter-intromission interval (MIII) and post-ejaculatory interval were prolonged in rats treated with 5-HT. These data provide evidence for the role of peripheral 5-HT in regulating sexual behavior of male rats.

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Year:  1982        PMID: 7154864     DOI: 10.1016/0024-3205(82)90724-x

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  2 in total

1.  Inhibitory effect of 5-hydroxytryptamine on penile erectile function in the rat.

Authors:  J P Finberg; Y Vardi
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

2.  Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats.

Authors:  Joseph J Normandin; Anne Z Murphy
Journal:  Pharmacol Biochem Behav       Date:  2011-02-03       Impact factor: 3.533

  2 in total

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