Literature DB >> 715443

Decrease in adrenergic axon sprouting in the senescent rat.

S W Scheff, L S Bernardo, C W Cotman.   

Abstract

When the septal area in young adult rats is denervated by a lesion of the fimbria-fornix, adrenergic fibers proliferate within the denervated area. The same operation performed on aged animals gives rise to a qualitatively similar but quantitatively less pronounced response. This reduction in reactive growth may reflect a decreased capacity of the aged brain to remodel its circuitry and restore lost function.

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Year:  1978        PMID： 715443     DOI： 10.1126/science.715443

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Reactive synaptogenesis in aging and Alzheimer's disease: lessons learned in the Cotman laboratory.

Authors:  Stephen Scheff
Journal:  Neurochem Res       Date:  2003-11       Impact factor: 3.996

2.  Aging profoundly delays functional recovery from gustatory nerve injury.

Authors:  L He; A Yadgarov; S Sharif; L P McCluskey
Journal:  Neuroscience       Date:  2012-02-21       Impact factor: 3.590

3.  Interaction of age and sex in sympathetic axon ingrowth into the hippocampus following septal afferent damage.

Authors:  T A Milner; R Loy
Journal:  Anat Embryol (Berl)       Date:  1980

4.  The triumph of age: science, gerontology, and ageism.

Authors:  R N BUTLER
Journal:  Bull N Y Acad Med       Date:  1982-05

5.  Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha.

Authors:  Jason M Askvig; John A Watt
Journal:  J Comp Neurol       Date:  2019-03-25       Impact factor: 3.215

6.  Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Authors:  D Rudman; M H Kutner; C M Rogers; M F Lubin; G A Fleming; R P Bain
Journal:  J Clin Invest       Date:  1981-05       Impact factor: 14.808

7.  Association of sympathetic axons in denervated hippocampus to intracerebral vasculature. I. Fluorescence histochemistry combining glyoxylic acid and pontamine sky blue.

Authors:  J F McGinty; T A Milner; R Loy
Journal:  Anat Embryol (Berl)       Date:  1982

8.  A general homeostatic principle following lesion induced dendritic remodeling.

Authors:  Steffen Platschek; Hermann Cuntz; Mario Vuksic; Thomas Deller; Peter Jedlicka
Journal:  Acta Neuropathol Commun       Date:  2016-02-25       Impact factor: 7.801

9.  Focal cerebral ischemia in the TNFalpha-transgenic rat.

Authors:  L Creed Pettigrew; Mark S Kindy; Stephen Scheff; Joe E Springer; Richard J Kryscio; Yizhao Li; David S Grass
Journal:  J Neuroinflammation       Date:  2008-10-23       Impact factor: 8.322
  9 in total

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