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Literature DB >> 7153929

Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig.

Abstract

1. Afferent discharges were recorded from nerve filaments dissected from the hepatic branch of the vagus nerve in the guinea-pig in situ. 2. A significant decrease in the discharge rate was observed following the administration of D-glucose into the portal vein but not after the administration of D-mannose, D-fructose, D-galactose, L-glucose, D-xylose or D-arabinose. 3. The mean discharge rate of these fibres was inversely related to the concentration of glucose in the portal blood. 4. These results suggest the existence of D-glucose 'sensors' in the liver which monitor the glucose concentration of portal blood.

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Year: 1982 PMID： 7153929 PMCID： PMC1197400 DOI： 10.1113/jphysiol.1982.sp014415

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

19 in total

1. The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf.

Authors: F R Bell; D J Watson
Journal: J Physiol Date: 1976-07 Impact factor: 5.182

10. The actions of two sensory neuropeptides, substance P and calcitonin gene-related peptide, on the canine hepatic arterial and portal vascular beds.

Authors: P G Withrington
Journal: Br J Pharmacol Date: 1992-10 Impact factor: 8.739

Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig.

1. The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf.

2. Inhibition of gastric electrical and mechanical activity by intraduodenal agents in pigs and the effects of vagotomy.

Review 3. [Olfactory-gustatory alliesthesia and food intake in humans].

4. Physiological role of pleasure.

5. Afferent impulse discharges from glucoreceptors in the liver of the guinea pig.

6. The effect of atropine on the insulin release caused by oral and intravenous glucose in human subjects.

7. Vagal glucoreceptors in the small intestine of the cat.

8. Effect of actively transported hexoses on afferent nerve discharge from rat small intestine.

9. An hepatic osmoreceptor mechanism in the rat: electrophysiological and behavioral studies.

10. Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus.

1. An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system.

2. Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia.

Review 3. The vagus nerve, food intake and obesity.

Review 4. Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis.

5. Glucose and the vagus: sensory cells savour sweet substances.

Review 6. Regulation of memory - from the adrenal medulla to liver to astrocytes to neurons.

7. Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia.

8. Blood glucose levels modulate efferent activity in the vagal supply to the rat liver.

9. Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons.

10. The actions of two sensory neuropeptides, substance P and calcitonin gene-related peptide, on the canine hepatic arterial and portal vascular beds.