Literature DB >> 7152477

Reduced level of cellular glucocorticoid receptors in patients with anorexia nervosa.

K Kontula, L C Andersson, M Huttunen, R Pelkonen.   

Abstract

Specific glucocorticoid receptors were measured in circulating mononuclear leukocytes from 12 patients with anorexia nervosa and 21 healthy control subjects. Cells from patients were found to contain a significantly (p less than 0.01) lower level of glucocorticoid receptor (3830 +/- 210 sites/cell, mean +/- SE) than those from controls (4930 +/- 250 sites/cell). A partial glucocorticoid receptor defect may well explain the abnormal cortisol metabolism and glucocorticoid resistance commonly found in patients with anorexia nervosa.

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Year:  1982        PMID： 7152477     DOI： 10.1055/s-2007-1019100

Source DB:  PubMed          Journal:  Horm Metab Res        ISSN： 0018-5043            Impact factor:   2.936


  10 in total

1.  Glucocorticoid receptors and depression.

Authors:  L J Whalley; N Borthwick; D Copolov; H Dick; J E Christie; G Fink
Journal:  Br Med J (Clin Res Ed)       Date:  1986-03-29

2.  Transient elevation of sweat electrolytes in anorexia nervosa: a sweat gland steroid receptor defect?

Authors:  J De Schepper; M Verboven; A Piepsz; C Sevens
Journal:  Eur J Pediatr       Date:  1987-11       Impact factor: 3.183

3.  Development of Cushing's disease in a patient with anorexia nervosa.

Authors:  K Kontula; P Mustajoki; A Paetau; R Pelkonen
Journal:  J Endocrinol Invest       Date:  1984-02       Impact factor: 4.256

4.  Apparent free cortisol concentrations in patients with anorexia nervosa at different stages of the disease.

Authors:  M Rolla; M G Del Chicca; A Andreoni; D Belliti; S De Vescovi; G Andreani; A Clerico
Journal:  J Endocrinol Invest       Date:  1984-06       Impact factor: 4.256

Review 5.  The psychopharmacotherapy of anorexia nervosa: clinical, neuroendocrine and metabolic aspects.

Authors:  G Abbate Daga; L Gianotti; V Mondelli; R Quartesan; S Fassino
Journal:  J Endocrinol Invest       Date:  2004-11       Impact factor: 4.256

6.  Evidence for a positive correlation between serum cortisol levels and IL-1beta production by peripheral mononuclear cells in anorexia nervosa.

Authors:  P Limone; A Biglino; F Bottino; B Forno; P Calvelli; S Fassino; C Berardi; P Ajmone-Catt; A Bertagna; R P Tarocco; G G Rovera; G M Molinatti
Journal:  J Endocrinol Invest       Date:  2000 Jul-Aug       Impact factor: 4.256

7.  The adrenal sensitivity to ACTH stimulation is preserved in anorexia nervosa.

Authors:  F Lanfranco; L Gianotti; A Picu; S Fassino; G Abbate Daga; V Mondelli; R Giordano; S Grottoli; E Ghigo; E Arvat
Journal:  J Endocrinol Invest       Date:  2004-05       Impact factor: 4.256

Review 8.  The endocrinopathies of anorexia nervosa.

Authors:  Lisa S Usdan; Lalita Khaodhiar; Caroline M Apovian
Journal:  Endocr Pract       Date:  2008-11       Impact factor: 3.443

9.  Usage of megestrol acetate in the treatment of anorexia-cachexia syndrome in the elderly.

Authors:  S-S Yeh; S Lovitt; M W Schuster
Journal:  J Nutr Health Aging       Date:  2009-05       Impact factor: 4.075

Review 10.  Anorexia Nervosa and the Immune System-A Narrative Review.

Authors:  Dennis Gibson; Philip S Mehler
Journal:  J Clin Med       Date:  2019-11-08       Impact factor: 4.241
  10 in total

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