Literature DB >> 7152039

Inhibition of electrogenic anion entry into rat liver mitochondria by N,N'-dicyclohexylcarbodiimide.

I W Warhurst, A P Dawson, M J Selwyn.   

Abstract

The carboxyl group reagent dicyclohexylcarbodiimide inhibits the electrogenic entry of Cl- and NO3-into rat liver mitochondria at alkaline pH. The inhibition is time dependent and 50% inhibition is obtained by the addition of 3-4 nmol DCCD/mg protein. The blockage of the pH-dependent anion-conducting pore appears to be unrelated to the other known actions of DCCD on rat liver mitochondria but seems similar to its effect on the uncoupling protein of brown adipose tissue.

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Year:  1982        PMID： 7152039     DOI： 10.1016/0014-5793(82)81110-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Identification of anion and cation pathways in the inner mitochondrial membrane by patch clamping of mouse liver mitoplasts.

Authors:  Y N Antonenko; K W Kinnally; H Tedeschi
Journal:  J Membr Biol       Date:  1991-11       Impact factor: 1.843

2.  Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.

Authors:  M D Brand; M K Al-Shawi; G C Brown; B D Price
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

3.  Alkaline pH, membrane potential, and magnesium cations are negative modulators of purine nucleotide inhibition of H+ and Cl- transport through the uncoupling protein of brown adipose tissue mitochondria.

Authors:  P Jezek; J Houstĕk; Z Drahota
Journal:  J Bioenerg Biomembr       Date:  1988-10       Impact factor: 2.945

4.  Ion permeability induction by the SH cross-linking reagents in rat liver mitochondria is inhibited by the free radical scavenger, butylhydroxytoluene.

Authors:  S A Novgorodov; E V Kultayeva; L S Yaguzhinsky; V V Lemeshko
Journal:  J Bioenerg Biomembr       Date:  1987-06       Impact factor: 2.945

5.  Respiration-dependent contraction of swollen heart mitochondria: participation of the K+/H+ antiporter.

Authors:  G P Brierley; M H Davis; D W Jung
Journal:  J Bioenerg Biomembr       Date:  1988-04       Impact factor: 2.945

Review 6.  Properties of the inner membrane anion channel in intact mitochondria.

Authors:  A D Beavis
Journal:  J Bioenerg Biomembr       Date:  1992-02       Impact factor: 2.945
  6 in total

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