Literature DB >> 7151851

The influence of protein binding on disopyramide clearance.

S M Bryson, J R Lawrence, W H Steele, B C Campbell, H L Elliott, D J Sumner.   

Abstract

Individual disopyramide clearance is not constant and previous studies have suggested that this may be time and/or concentration dependent. Steady state disopyramide concentrations were achieved in six volunteer subjects at each of three infusion rates. Drug analysis was by HPLC and protein binding was determined by ultrafiltration. The disopyramide free fraction was concentration dependent and marked interindividual variability was observed. Disopyramide clearance was independent of time but dependent on total plasma concentration. This can be completely explained by non-linear protein binding since free disopyramide clearance was observed to be independent of free concentration.

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Year:  1982        PMID： 7151851     DOI： 10.1007/bf00605997

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  7 in total

1.  The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.

Authors:  J L Cunningham; D D Shen; I Shudo; D L Azarnoff
Journal:  Clin Pharmacokinet       Date:  1977 Sep-Oct       Impact factor: 6.447

2.  High-pressure liquid chromatographic analysis of drugs in biological fluids. III. Analysis of disopyramide and its mono-N-dealkylated metabolite in plasma and urine.

Authors:  P J Meffin; S R Harpat; D C Harrison
Journal:  J Chromatogr       Date:  1977-02-21

3.  Role of concentration-dependent plasma protein binding in disopyramide disposition.

Authors:  P J Meffin; E W Robert; R A Winkle; S Harapat; F A Peters; D C Harrison
Journal:  J Pharmacokinet Biopharm       Date:  1979-02

4.  Protein binding and erythrocyte partitioning of disopyramide and its monodealkylated metabolite.

Authors:  P H Hinderling; J Bres; E R Garrett
Journal:  J Pharm Sci       Date:  1974-11       Impact factor: 3.534

5.  Measurement of drug displacement by continuous ultrafiltration.

Authors:  D S Campion; R Olsen
Journal:  J Pharm Sci       Date:  1974-02       Impact factor: 3.534

6.  The renal clearance of disopyramide after bolus intravenous injection.

Authors:  J R Lawrence; S M Bryson; D J Sumner; B C Campbell; B Whiting
Journal:  Biopharm Drug Dispos       Date:  1979 Oct-Dec       Impact factor: 1.627

7.  Plasma concentrations and protein binding of disopyramide and mono-N-dealkyldisopyramide during chronic oral disopyramide therapy.

Authors:  M L Aitio
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335
  7 in total
  6 in total

1.  Protein binding and drug clearance.

Authors:  M Rowland
Journal:  Clin Pharmacokinet       Date:  1984-01       Impact factor: 6.447

2.  Pharmacokinetic-pharmacodynamic analysis of unbound disopyramide directly measured in serial plasma samples in man.

Authors:  M Thibonnier; N H Holford; R A Upton; C D Blume; R L Williams
Journal:  J Pharmacokinet Biopharm       Date:  1984-12

3.  Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide.

Authors:  K M Giacomini; T F Blaschke
Journal:  Clin Pharmacokinet       Date:  1984-01       Impact factor: 6.447

Review 4.  Clinical pharmacokinetics of disopyramide.

Authors:  L A Siddoway; R L Woosley
Journal:  Clin Pharmacokinet       Date:  1986 May-Jun       Impact factor: 6.447

Review 5.  Disopyramide. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiac arrhythmias.

Authors:  R N Brogden; P A Todd
Journal:  Drugs       Date:  1987-08       Impact factor: 9.546

6.  In vivo interaction of the enantiomers of disopyramide in human subjects.

Authors:  K M Giacomini; W L Nelson; R A Pershe; L Valdivieso; K Turner-Tamiyasu; T F Blaschke
Journal:  J Pharmacokinet Biopharm       Date:  1986-08
  6 in total

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