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Literature DB >> 7150959

Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis.

Abstract

Neuronal responses to the iontophoretic application of acetylcholine, carbachol and nicotine were studied in rats, 2 or 3 weeks following bilateral lesions of the nucleus basalis region, and compared to those obtained in normal animals. The percentage of cortical neurons excited by acetylcholine and their individual sensitivity were higher in lesioned animals. Furthermore, the laminar distribution of the responses to acetylcholine and the proportion of responses to carbachol and nicotine were also modified.

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Year: 1982 PMID： 7150959 DOI： 10.1016/0006-8993(82)90406-1

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

5 in total

1. Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis.

Authors: I Miyai; S Ueno; S Yorifuji; H Fujimura; S Tarui
Journal: J Neural Transm Gen Sect Date: 1990

5. An iontophoretic study of the effects of alpha-amino-hydroxy-5-methyl-4-isoxazole propionic acid lesions of the nucleus basalis magnocellularis on cholinergic and GABAergic influences on frontal cortex neurones of rats.

Authors: F A Abdulla; M R Calaminici; V V Raevsky; J D Sinden; J A Gray; J D Stephenson
Journal: Exp Brain Res Date: 1994 Impact factor: 1.972

5 in total

Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis.

1. Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis.

2. Cholinergic depletion prevents expansion of topographic maps in somatosensory cortex.

3. Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

4. Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. II. Nicotinic mechanisms.

5. An iontophoretic study of the effects of alpha-amino-hydroxy-5-methyl-4-isoxazole propionic acid lesions of the nucleus basalis magnocellularis on cholinergic and GABAergic influences on frontal cortex neurones of rats.