Literature DB >> 715066

Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.

J Mertin, A Stackpoole.   

Abstract

Experimental allergic encephalomyelitis in Lewis rats was suppressed by treatment with essential fatty acids (EFA) given perorally. This treatment effect could be abolished by administration of a drug (Indomethacin) known to inhibit biosynthesis of certain prostaglandins from EFA. This observation suggests that the suppressive effect of EFA on cell-mediated immune reactions is brought about by EFA-derived prostaglandins.

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Year:  1978        PMID： 715066     DOI： 10.1016/0161-4630(78)90047-2

Source DB:  PubMed          Journal:  Prostaglandins Med        ISSN： 0161-4630


  9 in total

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3.  Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE).

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4.  Polyunsaturated fatty acids and colchicine in multiple sclerosis.

Authors:  D F Horrobin; T Botez; M I Botez
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5.  The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production.

Authors:  L S Harbige; L Layward; M M Morris-Downes; D C Dumonde; S Amor
Journal:  Clin Exp Immunol       Date:  2000-12       Impact factor: 4.330

6.  The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.

Authors:  J Mertin; A Stackpoole
Journal:  Clin Exp Immunol       Date:  1979-06       Impact factor: 4.330

7.  Effect of indomethacin treatment upon actively-induced and transferred experimental allergic encephalomyelitis (EAE) in Lewis rats.

Authors:  H Ovadia; P Y Paterson
Journal:  Clin Exp Immunol       Date:  1982-08       Impact factor: 4.330

8.  Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea-pig: suppression by continuous treatment.

Authors:  D Hughes; A B Keith; J Mertin; E A Caspary
Journal:  Clin Exp Immunol       Date:  1980-06       Impact factor: 4.330

9.  The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice.

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Journal:  BMC Neurosci       Date:  2017-01-24       Impact factor: 3.288
  9 in total

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