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Literature DB >> 7150268

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles.

Abstract

The direct actions of glucocorticoid hormones on protein turnover were studied in isolated soleus muscles. These steroids were found to decrease the rates of both protein synthesis and protein breakdown within 3 h and 4 h respectively. Synthetic steroids (e.g. dexamethasone) were found to be more potent than naturally secreted hormones (e.g. cortisol) in inducing these changes, but only at concentrations in vitro less than 10nm.

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7150268 PMCID： PMC1158634 DOI： 10.1042/bj2060641

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

1. Incorporation of C14-amino acids into protein of isolated diaphragms: role of the adrenal steroids.

Authors: I G WOOL; E I WEINSHELBAUM
Journal: Am J Physiol Date: 1959-11

2. A fluorometric method for the estimation of tyrosine in plasma and tissues.

Authors: T P WAALKES; S UDENFRIEND
Journal: J Lab Clin Med Date: 1957-11

3. Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues.

Authors: A L Goldberg; D F Goldspink
Journal: Am J Physiol Date: 1975-01

4. Corticosteroids and growth.

Authors: J N Loeb
Journal: N Engl J Med Date: 1976-09-02 Impact factor: 91.245

5. The binding of dexamethasone and triamcinolone acetonide to glucocorticoid receptors in rat skeletal muscle.

Authors: M Mayer; N Kaiser; R J Milholland; F Rosen
Journal: J Biol Chem Date: 1974-08-25 Impact factor: 5.157

Review 6. Mechanism of action of glucocorticoids.

Authors: E B Thompson; M E Lippman
Journal: Metabolism Date: 1974-02 Impact factor: 8.694

7. Properties of muscle and liver lysosomes in adrenalectomized rats.

Authors: T Berg; J W Bird
Journal: Acta Physiol Scand Date: 1970-07

8. The sedimentation of rat skeletal-muscle ribosomes. Effect of hydrocortisone, insulin and diet.

Authors: V R Young; S C Chen; J Macdonald
Journal: Biochem J Date: 1968-02 Impact factor: 3.857

9. Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of N tau-methylhistidine.

Authors: F M Tomas; H N Munro; V R Young
Journal: Biochem J Date: 1979-01-15 Impact factor: 3.857

10. Relative changes in the function of muscle ribosomes and mitochondria during the early phase of steroid-induced catabolism.

Authors: G R Bullock; E E Carter; P Elliott; R F Peters; P Simpson; A M White
Journal: Biochem J Date: 1972-05 Impact factor: 3.857

18 in total

10. Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging.

Authors: D Dardevet; C Sornet; D Taillandier; I Savary; D Attaix; J Grizard
Journal: J Clin Invest Date: 1995-11 Impact factor: 14.808

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles.

1. Incorporation of C14-amino acids into protein of isolated diaphragms: role of the adrenal steroids.

2. A fluorometric method for the estimation of tyrosine in plasma and tissues.

3. Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues.

4. Corticosteroids and growth.

5. The binding of dexamethasone and triamcinolone acetonide to glucocorticoid receptors in rat skeletal muscle.

Review 6. Mechanism of action of glucocorticoids.

7. Properties of muscle and liver lysosomes in adrenalectomized rats.

8. The sedimentation of rat skeletal-muscle ribosomes. Effect of hydrocortisone, insulin and diet.

9. Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of N tau-methylhistidine.

10. Relative changes in the function of muscle ribosomes and mitochondria during the early phase of steroid-induced catabolism.

Review 1. Psychological stress and aging: role of glucocorticoids (GCs).

2. Acute effects of corticosterone on tissue protein synthesis and insulin-sensitivity in rats in vivo.

Review 3. Regulation of protein turnover in skeletal and cardiac muscle.

Review 4. Multiple actions of beta-adrenergic agonists on skeletal muscle and adipose tissue.

5. Short-term effects of corticosterone treatment on muscle protein synthesis in relation to the response to feeding.

6. Exercise training fails to prevent glucocorticoid-induced muscle alterations in young growing rats.

7. The differing responses of four muscle types to dexamethasone treatment in the rat.

8. Changes in prostaglandin release associated with inhibition of muscle protein synthesis by dexamethasone.

9. Characteristics of alpha-aminoisobutyric acid transport in rat skeletal muscles.

10. Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging.