Literature DB >> 7149987

Effects of L-ascorbic acid supplementation on dieldrin toxicity in rats.

S K Bandyopadhyay, R K Tiwari, A Mitra, B Mukherjee, A Banerjee, G C Chatterjee.   

Abstract

Chronic dieldrin administration to rats (5 mg/kg/day) produced pathological changes in liver and kidney tissues. Dieldrin treated rats showed high levels of liver ascorbic acid and increased activities of inorganic pyrophosphatase in brain and glucose-6-phosphatase in liver. The activities of Mg2+-ATPase in liver and acetylcholinesterase in brain were decreased under toxic doses of dieldrin. L-Ascorbic acid supplements in treated animals could partially prevent the pathological alterations, as observed histologically in liver and kidney tissues. Administration of this vitamin could also prevent alterations in some enzyme activities produced by toxic dieldrin doses.

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Year:  1982        PMID： 7149987     DOI： 10.1007/bf00310854

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  Effect of chromium and tungsten on L-ascorbic acid metabolism in rats and chicks.

Authors:  G C Chatterjee; R K Roy; N Sasmal; S K Banerjee; P K Majumder
Journal:  J Nutr       Date:  1973-04       Impact factor: 4.798

2.  Hepatocellular adaptation and injury. Structural and biochemical changes following dieldrin and methyl butter yellow.

Authors:  F Hutterer; F M Klion; A Wengraf; F Schaffner; H Popper
Journal:  Lab Invest       Date:  1969-05       Impact factor: 5.662

3.  The toxicology and pharmacodynamics of dieldrin (HEOD): two-year oral exposures of rats and dogs.

Authors:  A I Walker; D E Stevenson; J Robinson; E Thorpe; M Roberts
Journal:  Toxicol Appl Pharmacol       Date:  1969-09       Impact factor: 4.219

4.  Studies on the protective effects of ascorbic acid in rubidium toxicity.

Authors:  G C Chatterjee; S Chatterjee; K Chatterjee; A Sahu; A Bhattacharyya; D Chakraborty; P K Das
Journal:  Toxicol Appl Pharmacol       Date:  1979-10       Impact factor: 4.219

5.  Content and activities of microsomal electron transport components during the development of dieldrin-induced hypertrophic hypoactive endoplasmic reticulum.

Authors:  J T Stevens; K M Oberholser; S R Wagner; F E Greene
Journal:  Toxicol Appl Pharmacol       Date:  1977-03       Impact factor: 4.219

6.  Ascorbic acid requirements and metabolism in relation to organochlorine pesticides.

Authors:  J C Street; R W Chadwick
Journal:  Ann N Y Acad Sci       Date:  1975-09-30       Impact factor: 5.691

7.  Studies on L-ascorbic acid metabolism in rats under chronic toxicity due to organophosphorus insecticides: effects of supplementation of L-ascorbic acid in high doses.

Authors:  D Chakraborty; A Bhattacharyya; K Majumdar; K Chatterjee; S Chatterjee; A Sen; G C Chatterjee
Journal:  J Nutr       Date:  1978-06       Impact factor: 4.798

8.  Studies on the protective effects of L-ascorbic acid in chronic chlordane toxicity.

Authors:  K Chatterjee; S K Banerjee; R Tiwari; K Mazumdar; A Bhattacharyya; G C Chatterjee
Journal:  Int J Vitam Nutr Res       Date:  1981       Impact factor: 1.784

9.  Biochemical studies on polychlorinated biphenyl toxicity in rats: manipulation by vitamin C.

Authors:  D Chakraborty; A Bhattacharyya; J Chatterjee; K Chatterjee; A Sen; S Chatterjee; K Majumdar; G C Chatterjee
Journal:  Int J Vitam Nutr Res       Date:  1978       Impact factor: 1.784
  9 in total

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