Literature DB >> 7147185

Bioactive antibiotic levels in the human aorta.

D Mutch, G Richards, R A Brown, D S Mulder.   

Abstract

A new bioassay was used to determine the level of active antibiotic within the aortic wall in 24 patients undergoing elective aortic surgery involving prosthetic grafts. The patients were divided into three groups and received either cefazolin, clindamycin, or cefoxitin intravenously at the induction of general anesthesia. Cefazolin and cefoxitin attained satisfactory tissue levels. Clindamycin did not reach therapeutic levels in the aortic wall. Blood levels did not correlate well with tissue levels.

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Year:  1982        PMID： 7147185

Source DB:  PubMed          Journal:  Surgery        ISSN： 0039-6060            Impact factor:   3.982


  9 in total

1.  Concentrations of ceftriaxone (1,000 milligrams intravenously) in abdominal tissues during open prostatectomy.

Authors:  C Martin; X Viviand; A Cottin; V Savelli; C Brousse; E Ragni; C Richaud; M N Mallet
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

2.  Teicoplanin in cardiac surgery: intraoperative pharmacokinetics and concentrations in cardiac and mediastinal tissues.

Authors:  C Martin; P Bourget; M Alaya; A Sertin; C Atlani; K Ennabli; R Said
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

3.  Penetration of vancomycin into mediastinal and cardiac tissues in humans.

Authors:  C Martin; M Alaya; M N Mallet; X Viviand; K Ennabli; R Said; P De Micco
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

4.  Pharmacokinetics and tissue penetration of a single dose of ornidazole (1,000 milligrams intravenously) for antibiotic prophylaxis in colorectal surgery.

Authors:  C Martin; B Bruguerolle; M N Mallet; M Condomines; B Sastre; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

5.  Penetration of ceftriaxone (1 or 2 grams intravenously) into mediastinal and cardiac tissues in humans.

Authors:  C Martin; X Viviand; M Alaya; F Lokiec; K Ennabli; R Said; M Pecking
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Comparison of concentrations of two doses of clavulanic acid (200 and 400 milligrams) administered with amoxicillin (2,000 milligrams) in tissues of patients undergoing colorectal surgery.

Authors:  C Martin; M N Mallet; B Sastre; X Viviand; A Martin; P De Micco; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

7.  Pharmacokinetics and tissue penetration of single-dose cefotetan used for antimicrobial prophylaxis in patients undergoing colorectal surgery.

Authors:  C Martin; C Portet; D Lambert; B Bruguerolle; B Sastre; P De Micco; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

8.  Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic prophylaxis in thoracic surgery.

Authors:  C Martin; J Ragni; F Lokiec; J C Guillen; A Auge; M Pecking; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

9.  Pharmacokinetics and tissue penetration of a single 1,000-milligram, intravenous dose of metronidazole for antibiotic prophylaxis of colorectal surgery.

Authors:  C Martin; B Sastre; M N Mallet; B Bruguerolle; J P Brun; P De Micco; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191
  9 in total

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