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Literature DB >> 7145466

Polyamine oxidase-mediated killing of African trypanosomes.

Abstract

African trypanosomes, Trypanosoma brucei brucei, T. vivax and T. congolense, were killed when incubated in vitro with ruminant sera in the presence of exogeneous spermidine, and were non-infective for mice. Purified polyamine oxidase in the presence of spermidine-mediated similar killing of trypanosomes. The abundance of polyamine oxidase activity in ruminant sera which can react with polyamines to produce products with cytotoxic properties may explain the trypanosome killing. This system may contribute to non-specific parasite killing in vivo.

Entities: Chemical Species

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Year: 1982 PMID： 7145466 DOI： 10.1111/j.1365-3024.1982.tb00446.x

Source DB: PubMed Journal: Parasite Immunol ISSN： 0141-9838 Impact factor: 2.280

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Cited

7 in total

1. Validation of spermidine synthase as a drug target in African trypanosomes.

Authors: Martin C Taylor; Harparkash Kaur; Bernard Blessington; John M Kelly; Shane R Wilkinson
Journal: Biochem J Date: 2008-01-15 Impact factor: 3.857

2. The trypanocidal Cape buffalo serum protein is xanthine oxidase.

Authors: M Muranjan; Q Wang; Y L Li; E Hamilton; F P Otieno-Omondi; J Wang; A Van Praagh; J G Grootenhuis; S J Black
Journal: Infect Immun Date: 1997-09 Impact factor: 3.441

3. Differences in sensitivity of Schistosoma mansoni schistosomula, Dirofilaria immitis microfilariae, and Nematospiroides dubius third-stage larvae to damage by the polyamine oxidase-polyamine system.

Authors: A Ferrante; I Ljungstrom; C M Rzepczyk; D M Morgan
Journal: Infect Immun Date: 1986-09 Impact factor: 3.441

4. Polyamine oxidase-mediated intraerythrocytic killing of Plasmodium falciparum: evidence against the role of reactive oxygen metabolites.

Authors: C M Rzepczyk; A J Saul; A Ferrante
Journal: Infect Immun Date: 1984-01 Impact factor: 3.441

Polyamine oxidase-mediated killing of African trypanosomes.

1. Validation of spermidine synthase as a drug target in African trypanosomes.

2. The trypanocidal Cape buffalo serum protein is xanthine oxidase.

3. Differences in sensitivity of Schistosoma mansoni schistosomula, Dirofilaria immitis microfilariae, and Nematospiroides dubius third-stage larvae to damage by the polyamine oxidase-polyamine system.

4. Polyamine oxidase-mediated intraerythrocytic killing of Plasmodium falciparum: evidence against the role of reactive oxygen metabolites.

5. Trypanolytic activity, agglutinins, and opsonins in sera from animals refractory to Trypanosoma lewisi.

6. Inhibition of human neutrophil locomotion by the polyamine oxidase-polyamine system.

7. Polyamine oxidase activity in rheumatoid arthritis synovial fluid.