| Literature DB >> 7144928 |
K Yoshida, J Engel, S Liljequist.
Abstract
The effect of chronic ethanol administration on high affinity 3H-nicotinic binding rat brain was investigated. Chronic ethanol administration for 5 months included a significant decrease in the number of specific nicotinic binding sites in the hippocampus, whereas a significantly increase in the number of nicotinic binding sites both in the hypothalamus and in the thalamus was found. Similar effects were observed both after administration of a lower concentration (8% W/V) ethanol and a higher concentration (16% W/V) indicating that the duration of the administration seems to be of importance for the biochemical changes observed.Entities:
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Year: 1982 PMID： 7144928 DOI： 10.1007/bf00586353
Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000