| Literature DB >> 71446 |
A Bennett, E M Charlier, A M McDonald, J S Simpson, I F Stamford, T Zebro.
Abstract
Malignant human breast tumours produced more prostaglandin-like material during homogenisation than did benign tumours or normal breast tissue. Greatest synthesis in vitro occurred with tumours associated with bone metastases, and the highest "basal" amounts tended to occur in tumours showing spread histologically. It is suggested that prostaglandins may play a part in tumour spread and growth in bone and that drugs which inhibit prostaglandin synthesis may be valuable therapeutic agents in cancer.Entities:
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Year: 1977 PMID： 71446 DOI： 10.1016/s0140-6736(77)92496-5
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321