Literature DB >> 7141386

A study of bile canalicular contractions in isolated hepatocytes.

M J Phillips, C Oshio, M Miyairi, H Katz, C R Smith.   

Abstract

Living hepatocytes observed under standard methods of cell isolation and culture show frequent active contractions of bile canaliculi when viewed by time-lapse cinephotomicrography. This report gives details of the methods used to show the contractions. In addition, the characteristics of the contraction pattern are defined and analyzed. The contractions are regular, canalicular contraction time (systole) lasts 60 sec, and the most probably interval between contractions is 5 1/2 min. The finding of a regular pattern of contraction suggests an ordered, programmed, and integrated mechanism which entails a high degree of communication and functional coordination between neighboring hepatocytes.

Mesh：

Year:  1982        PMID： 7141386     DOI： 10.1002/hep.1840020603

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


  16 in total

1.  Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets.

Authors:  Norihito Watanabe; Tatehiro Kagawa; Seiichiro Kojima; Shinji Takashimizu; Naruhiko Nagata; Yasuhiro Nishizaki; Tetsuya Mine
Journal:  World J Gastroenterol       Date:  2006-09-07       Impact factor: 5.742

2.  Intermediate filaments of hepatocytes and biliary epithelial cells in bile duct obstruction: transmission and scanning electron microscopy study.

Authors:  T Okanoue; M Ohta; K Kachi; Y Ohta; Y Sawa; H Kanaoka; K Kagawa; T Takino; S W French
Journal:  Gastroenterol Jpn       Date:  1988-08

3.  Effects of phalloidin and cytochalasin B on cytoskeletal structures in cultured rat hepatocytes.

Authors:  I Nickola; M Frimmer
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

4.  Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function.

Authors:  J Graf; A Gautam; J L Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

5.  "Varicoid change" of bile canaliculi in rat liver at an early phase of ischaemia-reperfusion injury.

Authors:  H Yasui; T Takamatsu; S Fujita
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

6.  Ca2+ causes active contraction of bile canaliculi: direct evidence from microinjection studies.

Authors:  S Watanabe; M J Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

7.  Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation.

Authors:  Cen Guo; Kyunghee Yang; Kenneth R Brouwer; Robert L St Claire; Kim L R Brouwer
Journal:  J Pharmacol Exp Ther       Date:  2016-05-27       Impact factor: 4.030

Review 8.  Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

Authors:  Kyunghee Yang; Cen Guo; Jeffrey L Woodhead; Robert L St Claire; Paul B Watkins; Scott Q Siler; Brett A Howell; Kim L R Brouwer
Journal:  J Pharm Sci       Date:  2016-02       Impact factor: 3.534

9.  Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes.

Authors:  LaToya M Griffin; Paul B Watkins; Cassandra H Perry; Robert L St Claire; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2012-10-22       Impact factor: 3.922

10.  Periportal- and perivenous-enriched hepatocyte couplets: differences in canalicular activity and in response to oxidative stress.

Authors:  J C Wilton; J K Chipman; C J Lawson; A J Strain; R Coleman
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.